Forskning ved Københavns Universitet - Københavns Universitet


The histone deacetylase inhibitor Trichostatin A modulates CD4+ T cell responses

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Histone deacetylase inhibitors (HDACIs) induce hyperacetylation of core histones modulating chromatin structure and affecting gene expression. These compounds are also able to induce growth arrest, cell differentiation, and apoptotic cell death of tumor cells in vitro as well as in vivo. Even though several genes modulated by HDAC inhibition have been identified, those genes clearly responsible for the biological effects of these drugs have remained elusive. We investigated the pharmacological effect of the HDACI and potential anti-cancer agent Trichostatin A (TSA) on primary T cells.
TidsskriftB M C Cancer
Sider (fra-til)30
StatusUdgivet - 2003

ID: 41043584