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The importance of fatty acids as nutrients during post-exercise recovery

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Standard

The importance of fatty acids as nutrients during post-exercise recovery. / Lundsgaard, Annemarie; Fritzen, Andreas Mæchel; Kiens, Bente.

I: Nutrients, Bind 12, Nr. 2, 280, 2020.

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

Harvard

Lundsgaard, A, Fritzen, AM & Kiens, B 2020, 'The importance of fatty acids as nutrients during post-exercise recovery', Nutrients, bind 12, nr. 2, 280. https://doi.org/10.3390/nu12020280

APA

Lundsgaard, A., Fritzen, A. M., & Kiens, B. (2020). The importance of fatty acids as nutrients during post-exercise recovery. Nutrients, 12(2), [280]. https://doi.org/10.3390/nu12020280

Vancouver

Lundsgaard A, Fritzen AM, Kiens B. The importance of fatty acids as nutrients during post-exercise recovery. Nutrients. 2020;12(2). 280. https://doi.org/10.3390/nu12020280

Author

Lundsgaard, Annemarie ; Fritzen, Andreas Mæchel ; Kiens, Bente. / The importance of fatty acids as nutrients during post-exercise recovery. I: Nutrients. 2020 ; Bind 12, Nr. 2.

Bibtex

@article{081c5d780e85421289b3a28c2b1c00d4,
title = "The importance of fatty acids as nutrients during post-exercise recovery",
abstract = "It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several hours following aerobic endurance exercise, even despite carbohydrate intake. However, the mechanisms involved herein have hitherto not been subject to a thorough evaluation. In immediate and early recovery (0-4 h), plasma FA availability is high, which seems mainly to be a result of hormonal factors and increased adipose tissue blood flow. The increased circulating availability of adipose-derived FA, coupled with FA from lipoprotein lipase (LPL)-derived very-low density lipoprotein (VLDL)-triacylglycerol (TG) hydrolysis in skeletal muscle capillaries and hydrolysis of TG within the muscle together act as substrates for the increased mitochondrial FA oxidation post-exercise. Within the skeletal muscle cells, increased reliance on FA oxidation likely results from enhanced FA uptake into the mitochondria through the carnitine palmitoyltransferase (CPT) 1 reaction, and concomitant AMP-activated protein kinase (AMPK)-mediated pyruvate dehydrogenase (PDH) inhibition of glucose oxidation. Together this allows glucose taken up by the skeletal muscles to be directed towards the resynthesis of glycogen. Besides being oxidized, FAs also seem to be crucial signaling molecules for peroxisome proliferator-activated receptor (PPAR) signaling post-exercise, and thus for induction of the exercise-induced FA oxidative gene adaptation program in skeletal muscle following exercise. Collectively, a high FA turnover in recovery seems essential to regain whole-body substrate homeostasis.",
keywords = "Faculty of Science, Post-exercise recovery, Fatty acid oxidation, Skeletal muscle, Lipid metabolism, Molecular mechanism, Adipose tissue lipolysis, AMP-activated protein kinase (AMPK), Pyruvate dehydrogenase (PDH), Carnitine palmitoyltransferase I (CPT1), Lipoprotein lipase (LPL)",
author = "Annemarie Lundsgaard and Fritzen, {Andreas M{\ae}chel} and Bente Kiens",
note = "CURIS 2020 NEXS 044",
year = "2020",
doi = "10.3390/nu12020280",
language = "English",
volume = "12",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - The importance of fatty acids as nutrients during post-exercise recovery

AU - Lundsgaard, Annemarie

AU - Fritzen, Andreas Mæchel

AU - Kiens, Bente

N1 - CURIS 2020 NEXS 044

PY - 2020

Y1 - 2020

N2 - It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several hours following aerobic endurance exercise, even despite carbohydrate intake. However, the mechanisms involved herein have hitherto not been subject to a thorough evaluation. In immediate and early recovery (0-4 h), plasma FA availability is high, which seems mainly to be a result of hormonal factors and increased adipose tissue blood flow. The increased circulating availability of adipose-derived FA, coupled with FA from lipoprotein lipase (LPL)-derived very-low density lipoprotein (VLDL)-triacylglycerol (TG) hydrolysis in skeletal muscle capillaries and hydrolysis of TG within the muscle together act as substrates for the increased mitochondrial FA oxidation post-exercise. Within the skeletal muscle cells, increased reliance on FA oxidation likely results from enhanced FA uptake into the mitochondria through the carnitine palmitoyltransferase (CPT) 1 reaction, and concomitant AMP-activated protein kinase (AMPK)-mediated pyruvate dehydrogenase (PDH) inhibition of glucose oxidation. Together this allows glucose taken up by the skeletal muscles to be directed towards the resynthesis of glycogen. Besides being oxidized, FAs also seem to be crucial signaling molecules for peroxisome proliferator-activated receptor (PPAR) signaling post-exercise, and thus for induction of the exercise-induced FA oxidative gene adaptation program in skeletal muscle following exercise. Collectively, a high FA turnover in recovery seems essential to regain whole-body substrate homeostasis.

AB - It is well recognized that whole-body fatty acid (FA) oxidation remains increased for several hours following aerobic endurance exercise, even despite carbohydrate intake. However, the mechanisms involved herein have hitherto not been subject to a thorough evaluation. In immediate and early recovery (0-4 h), plasma FA availability is high, which seems mainly to be a result of hormonal factors and increased adipose tissue blood flow. The increased circulating availability of adipose-derived FA, coupled with FA from lipoprotein lipase (LPL)-derived very-low density lipoprotein (VLDL)-triacylglycerol (TG) hydrolysis in skeletal muscle capillaries and hydrolysis of TG within the muscle together act as substrates for the increased mitochondrial FA oxidation post-exercise. Within the skeletal muscle cells, increased reliance on FA oxidation likely results from enhanced FA uptake into the mitochondria through the carnitine palmitoyltransferase (CPT) 1 reaction, and concomitant AMP-activated protein kinase (AMPK)-mediated pyruvate dehydrogenase (PDH) inhibition of glucose oxidation. Together this allows glucose taken up by the skeletal muscles to be directed towards the resynthesis of glycogen. Besides being oxidized, FAs also seem to be crucial signaling molecules for peroxisome proliferator-activated receptor (PPAR) signaling post-exercise, and thus for induction of the exercise-induced FA oxidative gene adaptation program in skeletal muscle following exercise. Collectively, a high FA turnover in recovery seems essential to regain whole-body substrate homeostasis.

KW - Faculty of Science

KW - Post-exercise recovery

KW - Fatty acid oxidation

KW - Skeletal muscle

KW - Lipid metabolism

KW - Molecular mechanism

KW - Adipose tissue lipolysis

KW - AMP-activated protein kinase (AMPK)

KW - Pyruvate dehydrogenase (PDH)

KW - Carnitine palmitoyltransferase I (CPT1)

KW - Lipoprotein lipase (LPL)

U2 - 10.3390/nu12020280

DO - 10.3390/nu12020280

M3 - Review

C2 - 31973165

VL - 12

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 280

ER -

ID: 237511361