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The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

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Standard

The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. / Agger, Karl; Nishimura, Koutarou; Miyagi, Satoru; Messling, Jan-Erik; Rasmussen, Kasper Dindler; Helin, Kristian.

I: Blood, Bind 134, Nr. 14, 2019, s. 1154-1158.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Agger, K, Nishimura, K, Miyagi, S, Messling, J-E, Rasmussen, KD & Helin, K 2019, 'The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance', Blood, bind 134, nr. 14, s. 1154-1158. https://doi.org/10.1182/blood.2019000855

APA

Agger, K., Nishimura, K., Miyagi, S., Messling, J-E., Rasmussen, K. D., & Helin, K. (2019). The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. Blood, 134(14), 1154-1158. https://doi.org/10.1182/blood.2019000855

Vancouver

Agger K, Nishimura K, Miyagi S, Messling J-E, Rasmussen KD, Helin K. The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. Blood. 2019;134(14):1154-1158. https://doi.org/10.1182/blood.2019000855

Author

Agger, Karl ; Nishimura, Koutarou ; Miyagi, Satoru ; Messling, Jan-Erik ; Rasmussen, Kasper Dindler ; Helin, Kristian. / The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance. I: Blood. 2019 ; Bind 134, Nr. 14. s. 1154-1158.

Bibtex

@article{806280f73c564071a16fb7c6d644e537,
title = "The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance",
abstract = "KDM4/JMJD2 are H3K9- and H3K36- specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL-translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential side effects of continuous inhibition of these enzymes. Utilizing conditional Kdm4a/Kdm4b/Kdm4c triple-knockout mice we show that KDM4 activity is required for hematopoietic stem cell (HSC) maintenance in vivo The knockout of the KDM4 demethylases leads to accumulation of H3K9me3 on transcription start sites and the corresponding downregulation of expression of several genes in hematopoietic stem cells. We show that two of these genes, Taf1band Nom1, are essential for the maintenance of hematopoietic cells. Taken together, our results show that the KDM4 demethylases are required for the expression of genes essential for the long-term maintenance of normal hematopoiesis.",
author = "Karl Agger and Koutarou Nishimura and Satoru Miyagi and Jan-Erik Messling and Rasmussen, {Kasper Dindler} and Kristian Helin",
note = "Copyright {\circledC} 2019 American Society of Hematology.",
year = "2019",
doi = "10.1182/blood.2019000855",
language = "English",
volume = "134",
pages = "1154--1158",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "14",

}

RIS

TY - JOUR

T1 - The KDM4/JMJD2 histone demethylases are required for hematopoietic stem cell maintenance

AU - Agger, Karl

AU - Nishimura, Koutarou

AU - Miyagi, Satoru

AU - Messling, Jan-Erik

AU - Rasmussen, Kasper Dindler

AU - Helin, Kristian

N1 - Copyright © 2019 American Society of Hematology.

PY - 2019

Y1 - 2019

N2 - KDM4/JMJD2 are H3K9- and H3K36- specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL-translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential side effects of continuous inhibition of these enzymes. Utilizing conditional Kdm4a/Kdm4b/Kdm4c triple-knockout mice we show that KDM4 activity is required for hematopoietic stem cell (HSC) maintenance in vivo The knockout of the KDM4 demethylases leads to accumulation of H3K9me3 on transcription start sites and the corresponding downregulation of expression of several genes in hematopoietic stem cells. We show that two of these genes, Taf1band Nom1, are essential for the maintenance of hematopoietic cells. Taken together, our results show that the KDM4 demethylases are required for the expression of genes essential for the long-term maintenance of normal hematopoiesis.

AB - KDM4/JMJD2 are H3K9- and H3K36- specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL-translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential side effects of continuous inhibition of these enzymes. Utilizing conditional Kdm4a/Kdm4b/Kdm4c triple-knockout mice we show that KDM4 activity is required for hematopoietic stem cell (HSC) maintenance in vivo The knockout of the KDM4 demethylases leads to accumulation of H3K9me3 on transcription start sites and the corresponding downregulation of expression of several genes in hematopoietic stem cells. We show that two of these genes, Taf1band Nom1, are essential for the maintenance of hematopoietic cells. Taken together, our results show that the KDM4 demethylases are required for the expression of genes essential for the long-term maintenance of normal hematopoiesis.

U2 - 10.1182/blood.2019000855

DO - 10.1182/blood.2019000855

M3 - Journal article

C2 - 31434704

VL - 134

SP - 1154

EP - 1158

JO - Blood

JF - Blood

SN - 0006-4971

IS - 14

ER -

ID: 227413339