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The microcephalin ancestral allele in a Neanderthal individual

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Martina Lari, Ermanno Rizzi, Lucio Milani, Giorgio Corti, Carlotta Balsamo, Stefania Vai, Giulio Catalano, Elena Pilli, Laura Longo, Silvana Condemi, Paolo Giunti, Catherine Hänni, Gianluca De Bellis, Ludovic Antoine Alexandre Orlando, Guido Barbujani, David Caramelli

The high frequency (around 0.70 worldwide) and the relatively young age (between 14,000 and 62,000 years) of a derived group of haplotypes, haplogroup D, at the microcephalin (MCPH1) locus led to the proposal that haplogroup D originated in a human lineage that separated from modern humans >1 million years ago, evolved under strong positive selection, and passed into the human gene pool by an episode of admixture circa 37,000 years ago. The geographic distribution of haplogroup D, with marked differences between Africa and Eurasia, suggested that the archaic human form admixing with anatomically modern humans might have been Neanderthal.
TidsskriftP L o S One
Antal sider6
StatusUdgivet - 2010
Eksternt udgivetJa

ID: 33910627