Forskning ved Københavns Universitet - Københavns Universitet


The OMERACT rheumatoid arthritis magnetic resonance imaging (MRI) scoring system: Updated recommendations by the OMERACT MRI in arthritis working group

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Østergaard, Mikkel
  • Charles G. Peterfy
  • Paul Bird
  • Frédérique Gandjbakhch
  • Daniel Glinatsi
  • Iris Eshed
  • Espen A. Haavardsholm
  • Siri Lillegraven
  • Pernille Bøyesen
  • Bo Ejbjerg
  • Violaine Foltz
  • Paul Emery
  • Harry K. Genant
  • Philip G. Conaghan

Objective: The Outcome Measures in Rheumatology (OMERACT) Rheumatoid Arthritis (RA) Magnetic Resonance Imaging (MRI) scoring system (RAMRIS), evaluating bone erosion, bone marrow edema/osteitis, and synovitis, was introduced in 2002, and is now the standard method of objectively quantifying inflammation and damage by MRI in RA trials. The objective of this paper was to identify subsequent advances and based on them, to provide updated recommendations for the RAMRIS. Methods: MRI studies relevant for RAMRIS and technical and scientific advances were analyzed by the OMERACT MRI in Arthritis Working Group, which used these data to provide updated considerations on image acquisition, RAMRIS definitions, and scoring systems for the original and new RA pathologies. Further, a research agenda was outlined. Results: Since 2002, longitudinal studies and clinical trials have documented RAMRIS variables to have face, construct, and criterion validity; high reliability and sensitivity to change; and the ability to discriminate between therapies. This has enabled RAMRIS to demonstrate inhibition of structural damage progression with fewer patients and shorter followup times than has been possible with conventional radiography. Technical improvements, including higher field strengths and improved pulse sequences, allow higher image resolution and contrast-to-noise ratio. These have facilitated development and validation of scoring methods of new pathologies: joint space narrowing and tenosynovitis. These have high reproducibility and moderate sensitivity to change, and can be added to RAMRIS. Combined scores of inflammation or joint damage may increase sensitivity to change and discriminative power. However, this requires further research. Conclusion: Updated 2016 RAMRIS recommendations and a research agenda were developed. The Journal of Rheumatology

TidsskriftJournal of Rheumatology
Udgave nummer11
Sider (fra-til)1706-1712
Antal sider7
StatusUdgivet - 1 nov. 2017

ID: 188356507