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The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae

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  • Thomas Didion
  • Regenberg, Birgitte
  • Marianne U. Jørgensen
  • Morten C. Kielland-Brandt
  • Helge A. Andersen

Amino acid transporters of the yeast plasma membrane (permeases) belong to a family of integral membrane proteins with pronounced structural similarity. We present evidence that a member of this family, encoded by the open reading frame (ORF) YDR160w (SSY1), is required for the expression of a set of transporter genes. Thus, deletion of the SSY1 gene causes loss of leucine-inducible transcription of the amino acid permease genes BAP2, TAT1 and BAP3 (ORF YDR046c) and the peptide transporter, PTR2. D-leucine can generate the signal without entering the cell. We propose that Ssy1p is situated in the plasma membrane and is involved in sensing leucine in the medium.

OriginalsprogEngelsk
TidsskriftMolecular Microbiology
Vol/bind27
Udgave nummer3
Sider (fra-til)643-650
Antal sider8
ISSN0950-382X
DOI
StatusUdgivet - 3 feb. 1998

ID: 239906386