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The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma. / Madsen, F; Holstein-Rathlou, N H; Mosbech, H; Weeke, B; Svendsen, U G.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 45, Nr. 5, 1985, s. 453-60.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Madsen, F, Holstein-Rathlou, NH, Mosbech, H, Weeke, B & Svendsen, UG 1985, 'The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma.', Scandinavian Journal of Clinical & Laboratory Investigation, bind 45, nr. 5, s. 453-60.

APA

Madsen, F., Holstein-Rathlou, N. H., Mosbech, H., Weeke, B., & Svendsen, U. G. (1985). The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma. Scandinavian Journal of Clinical & Laboratory Investigation, 45(5), 453-60.

Vancouver

Madsen F, Holstein-Rathlou NH, Mosbech H, Weeke B, Svendsen UG. The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma. Scandinavian Journal of Clinical & Laboratory Investigation. 1985;45(5):453-60.

Author

Madsen, F ; Holstein-Rathlou, N H ; Mosbech, H ; Weeke, B ; Svendsen, U G. / The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma. I: Scandinavian Journal of Clinical & Laboratory Investigation. 1985 ; Bind 45, Nr. 5. s. 453-60.

Bibtex

@article{b4b56e00abf111ddb5e9000ea68e967b,
title = "The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma.",
abstract = "A prospective survey aiming to study the predictive value of bronchial histamine challenge was performed on 151 patients with a forced expiratory volume1 (FEV1) above 60{\%} of predicted. According to variations in peak expiratory flow rate (PEFR) and medical history the patients were classified as asthmatics (n = 97) or non-asthmatics (n = 54). The diagnostic properties of the challenge were calculated using the statement of Baye. Considering PC20 values below 4.00 mg/ml as positive, the predictive value of a positive test was about 0.80 and the predictive value of a negative about 0.76. When PC20 was below 0.125 mg/ml the predictive value of a positive test was 1.00, but an increase in PC20 in the range from 4.00 to 16 mg/ml did not increase the predictive value of a negative test. In this study the prevalence of asthma was about 0.6. We therefore conclude that bronchial histamine challenge is a valuable test for detection and exclusion of bronchial asthma, when the prevalence of the disease is high. In populations with a lower frequency of bronchial asthma the diagnostic value of a positive bronchial challenge will be negligible.",
author = "F Madsen and Holstein-Rathlou, {N H} and H Mosbech and B Weeke and Svendsen, {U G}",
note = "Keywords: Adolescent; Adult; Aged; Asthma; Female; Forced Expiratory Volume; Histamine; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Prospective Studies",
year = "1985",
language = "English",
volume = "45",
pages = "453--60",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - The predictive value of bronchial histamine challenge in the diagnosis of bronchial asthma.

AU - Madsen, F

AU - Holstein-Rathlou, N H

AU - Mosbech, H

AU - Weeke, B

AU - Svendsen, U G

N1 - Keywords: Adolescent; Adult; Aged; Asthma; Female; Forced Expiratory Volume; Histamine; Humans; Male; Middle Aged; Peak Expiratory Flow Rate; Prospective Studies

PY - 1985

Y1 - 1985

N2 - A prospective survey aiming to study the predictive value of bronchial histamine challenge was performed on 151 patients with a forced expiratory volume1 (FEV1) above 60% of predicted. According to variations in peak expiratory flow rate (PEFR) and medical history the patients were classified as asthmatics (n = 97) or non-asthmatics (n = 54). The diagnostic properties of the challenge were calculated using the statement of Baye. Considering PC20 values below 4.00 mg/ml as positive, the predictive value of a positive test was about 0.80 and the predictive value of a negative about 0.76. When PC20 was below 0.125 mg/ml the predictive value of a positive test was 1.00, but an increase in PC20 in the range from 4.00 to 16 mg/ml did not increase the predictive value of a negative test. In this study the prevalence of asthma was about 0.6. We therefore conclude that bronchial histamine challenge is a valuable test for detection and exclusion of bronchial asthma, when the prevalence of the disease is high. In populations with a lower frequency of bronchial asthma the diagnostic value of a positive bronchial challenge will be negligible.

AB - A prospective survey aiming to study the predictive value of bronchial histamine challenge was performed on 151 patients with a forced expiratory volume1 (FEV1) above 60% of predicted. According to variations in peak expiratory flow rate (PEFR) and medical history the patients were classified as asthmatics (n = 97) or non-asthmatics (n = 54). The diagnostic properties of the challenge were calculated using the statement of Baye. Considering PC20 values below 4.00 mg/ml as positive, the predictive value of a positive test was about 0.80 and the predictive value of a negative about 0.76. When PC20 was below 0.125 mg/ml the predictive value of a positive test was 1.00, but an increase in PC20 in the range from 4.00 to 16 mg/ml did not increase the predictive value of a negative test. In this study the prevalence of asthma was about 0.6. We therefore conclude that bronchial histamine challenge is a valuable test for detection and exclusion of bronchial asthma, when the prevalence of the disease is high. In populations with a lower frequency of bronchial asthma the diagnostic value of a positive bronchial challenge will be negligible.

M3 - Journal article

C2 - 4035282

VL - 45

SP - 453

EP - 460

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 5

ER -

ID: 8440522