Forskning ved Københavns Universitet - Københavns Universitet


The probability and chromosomal extent of trans-specific polymorphism

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Balancing selection may result in tans-specific polymorphism: the maintenance of allelic classes that transcend species boundaries by virtue of being more ancient than the species themselves. At the selected site, gene genealogies are expected not to reflect the species tree. Because of linkage, the same will be true for part of the surrounding chromosomal region. Here we obtain various approximations for the distribution of the length of this region and discuss the practical implications of our results. Our main finding is that the trans-specific region surrounding a single-locus balanced polymorphism is expected to be quite short, probably too short to be readily detectable. Thus lack of obvious trans-specific polymorphism should not be taken as evidence against balancing selection. When trans-specific polymorphism is obvious, on the other hand, it may be reasonable to argue that selection must be acting on multiple sites or that recombination is suppressed in the surrounding region.

Udgave nummer4
Sider (fra-til)2363-2372
Antal sider10
StatusUdgivet - 1 dec. 2004
Eksternt udgivetJa

ID: 203902591