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The Salt-Inducible Kinases: Emerging Metabolic Regulators

Publikation: Bidrag til tidsskriftReviewForskningfagfællebedømt

The discovery of liver kinase B1 (LKB1) as an upstream kinase for AMP-activated protein kinase (AMPK) led to the identification of several related kinases that also rely on LKB1 for their catalytic activity. Among these, the salt-inducible kinases (SIKs) have emerged as key regulators of metabolism. Unlike AMPK, SIKs do not respond to nucleotides, but their function is regulated by extracellular signals, such as hormones, through complex LKB1-independent mechanisms. While AMPK acts on multiple targets, including metabolic enzymes, to maintain cellular ATP levels, SIKs primarily regulate gene expression, by acting on transcriptional regulators, such as the cAMP response element-binding protein-regulated transcription coactivators and class IIa histone deacetylases. This review describes the development of research on SIKs, from their discovery to the most recent findings on metabolic regulation.

OriginalsprogEngelsk
TidsskriftTrends in Endocrinology and Metabolism
Vol/bind29
Udgave nummer12
Sider (fra-til)827-840
Antal sider14
ISSN1043-2760
DOI
StatusUdgivet - dec. 2018
Eksternt udgivetJa

ID: 238433124