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The spectrum of intermediate SCN8A-related epilepsy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Katrine M. Johannesen
  • Elena Gardella
  • Alejandra C. Encinas
  • Anna Elina Lehesjoki
  • Tarja Linnankivi
  • Michael B. Petersen
  • Ida Charlotte Bay Lund
  • Susanne Blichfeldt
  • Deb K. Pal
  • Karine Lascelles
  • Peter Procopis
  • Alessandro Orsini
  • Alice Bonuccelli
  • Thea Giacomini
  • Ingo Helbig
  • Christina D. Fenger
  • Sanjay M. Sisodiya
  • Laura Hernandez-Hernandez
  • Sundararaman Krithika
  • Melissa Rumple
  • Silvia Masnada
  • Marialuisa Valente
  • Cristina Cereda
  • Lucio Giordano
  • Patrizia Accorsi
  • Sarah E. Bürki
  • Margherita Mancardi
  • Christian Korff
  • Renzo Guerrini
  • Sarah von Spiczak
  • Dorota Hoffman-Zacharska
  • Tomasz Mazurczak
  • Antonietta Coppola
  • Salvatore Buono
  • Marilena Vecchi
  • Michael F. Hammer
  • Costanza Varesio
  • Pierangelo Veggiotti
  • Dennis Lal
  • Tobias Brünger
  • Federico Zara
  • Pasquale Striano
  • Rikke S. Møller

Objective: Pathogenic variants in SCN8A have been associated with a wide spectrum of epilepsy phenotypes, ranging from benign familial infantile seizures (BFIS) to epileptic encephalopathies with variable severity. Furthermore, a few patients with intellectual disability (ID) or movement disorders without epilepsy have been reported. The vast majority of the published SCN8A patients suffer from severe developmental and epileptic encephalopathy (DEE). In this study, we aimed to provide further insight on the spectrum of milder SCN8A-related epilepsies. Methods: A cohort of 1095 patients were screened using a next generation sequencing panel. Further patients were ascertained from a network of epilepsy genetics clinics. Patients with severe DEE and BFIS were excluded from the study. Results: We found 36 probands who presented with an SCN8A-related epilepsy and normal intellect (33%) or mild (61%) to moderate ID (6%). All patients presented with epilepsy between age 1.5 months and 7 years (mean = 13.6 months), and 58% of these became seizure-free, two-thirds on monotherapy. Neurological disturbances included ataxia (28%) and hypotonia (19%) as the most prominent features. Interictal electroencephalogram was normal in 41%. Several recurrent variants were observed, including Ile763Val, Val891Met, Gly1475Arg, Gly1483Lys, Phe1588Leu, Arg1617Gln, Ala1650Val/Thr, Arg1872Gln, and Asn1877Ser. Significance: With this study, we explore the electroclinical features of an intermediate SCN8A-related epilepsy with mild cognitive impairment, which is for the majority a treatable epilepsy.

OriginalsprogEngelsk
TidsskriftEpilepsia
Vol/bind60
Udgave nummer5
Sider (fra-til)830-844
Antal sider15
ISSN0013-9580
DOI
StatusUdgivet - 2019

ID: 238964873