Forskning ved Københavns Universitet - Københavns Universitet

Forside

Thymic epithelial cells. I. Expression of strong suppressive (veto) activity in mouse thymic epithelial cell cultures

Publikation: Forskning - peer reviewTidsskriftartikel

Mogens Helweg Claesson, C Ropke

We show that thymic epithelial cells grown under serum-free conditions in a chemically defined culture medium can act as veto cells in vitro. The veto activity of thymic epithelial cells results in inactivation of specific alloreactive cytotoxic T-cell precursors at the clonal level. It is concluded that the epithelial stromal cells of the thymus, by acting as veto cells, may be responsible for the negative intrathymic selection of self-reactive thymocytes leading to elimination of the vast majority of immature thymic lymphocytes.
OriginalsprogEngelsk
TidsskriftScandinavian journal of immunology
Vol/bind32
Tidsskriftsnummer6
Sider (fra-til)595-600
Antal sider6
ISSN0300-9475
StatusUdgivet - 1 dec. 1990

ID: 33022701