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Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

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Thymus gland size during recovery from complicated severe acute malnutrition : A prospective study of the role of probiotics. / Nabukeera Barungi, Nicolette; Grenov, Benedikte; Friis, Henrik; Lanyero, Betty; Namusoke, Hanifa; Mupere, Ezekiel; Michaelsen, Kim F.; Mølgaard, Christian; Christensen, Vibeke Bak; Rytter, Maren Johanne Heilskov.

I: Paediatrics and international child health, Bind 39, Nr. 2, 2019, s. 95-103.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Nabukeera Barungi, N, Grenov, B, Friis, H, Lanyero, B, Namusoke, H, Mupere, E, Michaelsen, KF, Mølgaard, C, Christensen, VB & Rytter, MJH 2019, 'Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics', Paediatrics and international child health, bind 39, nr. 2, s. 95-103. https://doi.org/10.1080/20469047.2018.1535871

APA

Nabukeera Barungi, N., Grenov, B., Friis, H., Lanyero, B., Namusoke, H., Mupere, E., Michaelsen, K. F., Mølgaard, C., Christensen, V. B., & Rytter, M. J. H. (2019). Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics. Paediatrics and international child health, 39(2), 95-103. https://doi.org/10.1080/20469047.2018.1535871

Vancouver

Nabukeera Barungi N, Grenov B, Friis H, Lanyero B, Namusoke H, Mupere E o.a. Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics. Paediatrics and international child health. 2019;39(2):95-103. https://doi.org/10.1080/20469047.2018.1535871

Author

Nabukeera Barungi, Nicolette ; Grenov, Benedikte ; Friis, Henrik ; Lanyero, Betty ; Namusoke, Hanifa ; Mupere, Ezekiel ; Michaelsen, Kim F. ; Mølgaard, Christian ; Christensen, Vibeke Bak ; Rytter, Maren Johanne Heilskov. / Thymus gland size during recovery from complicated severe acute malnutrition : A prospective study of the role of probiotics. I: Paediatrics and international child health. 2019 ; Bind 39, Nr. 2. s. 95-103.

Bibtex

@article{eabd1461fc0444b99412b720972aec78,
title = "Thymus gland size during recovery from complicated severe acute malnutrition: A prospective study of the role of probiotics",
abstract = "Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95%CI -0.25; -0.01), dermatosis (β -0.21, 95%CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95%CI -0.25; -0.02) and neutrophils (β -0.01, 95%CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.",
keywords = "Faculty of Science, Probiotics, Severe malnutrition, Thymus recovery",
author = "{Nabukeera Barungi}, Nicolette and Benedikte Grenov and Henrik Friis and Betty Lanyero and Hanifa Namusoke and Ezekiel Mupere and Michaelsen, {Kim F.} and Christian M{\o}lgaard and Christensen, {Vibeke Bak} and Rytter, {Maren Johanne Heilskov}",
note = "CURIS 2019 NEXS 192",
year = "2019",
doi = "10.1080/20469047.2018.1535871",
language = "English",
volume = "39",
pages = "95--103",
journal = "Paediatrics and international child health",
issn = "2046-9047",
publisher = "Maney Publishing",
number = "2",

}

RIS

TY - JOUR

T1 - Thymus gland size during recovery from complicated severe acute malnutrition

T2 - A prospective study of the role of probiotics

AU - Nabukeera Barungi, Nicolette

AU - Grenov, Benedikte

AU - Friis, Henrik

AU - Lanyero, Betty

AU - Namusoke, Hanifa

AU - Mupere, Ezekiel

AU - Michaelsen, Kim F.

AU - Mølgaard, Christian

AU - Christensen, Vibeke Bak

AU - Rytter, Maren Johanne Heilskov

N1 - CURIS 2019 NEXS 192

PY - 2019

Y1 - 2019

N2 - Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95%CI -0.25; -0.01), dermatosis (β -0.21, 95%CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95%CI -0.25; -0.02) and neutrophils (β -0.01, 95%CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.

AB - Background: Children with severe acute malnutrition (SAM) are prone to infections due to immune dysfunction including severe thymus atrophy which recovers during nutritional rehabilitation.Aim: To investigate predictors of thymus size recovery, including probiotics during nutritional rehabilitation of children admitted with complicated SAM.Methods: In this prospective study nested in a randomized controlled trial, children 6-59 months admitted with SAM received standard care and either probiotics or placebo during hospitalization until 8 weeks post-discharge. Thymus size was measured using ultrasound at admission, discharge, 8 weeks post-discharge and among 27 community controls. Predictors of thymus size recovery were assessed using linear regression.Results: Among 388 children with SAM, mean (SD) thymus size was 1.06 cm2 (0.41), 1.24 cm2 (0.48), 2.85 cm2 (1.07) and 4.2 cm2 (0.93) at admission, discharge, follow-up and in the healthy controls respectively (p < 0.05).Probiotics did not affect thymus recovery. During both inpatient therapeutic care (ITC) and outpatient therapeutic care (OTC), thymus recovery correlated positively with anthropometry but negatively with caregiver-perceived illness severity and Haemoglobin <8 g/dl. Negative predictors of thymus recovery during ITC included grade 3 oedema (β -0.13, 95%CI -0.25; -0.01), dermatosis (β -0.21, 95%CI -0.41; -0.01), C-reactive protein (CRP) >15mg/L (β -0.13, 95%CI -0.25; -0.02) and neutrophils (β -0.01, 95%CI -0.02; -0.002). During OTC, HIV negatively predicted thymus recovery.Conclusion: Children with SAM failed to regain thymus size at 8 weeks post-discharge. Probiotics did not predict thymus recovery during nutritional rehabilitation. More research is needed to find interventions which can accelerate immune recovery.

KW - Faculty of Science

KW - Probiotics

KW - Severe malnutrition

KW - Thymus recovery

U2 - 10.1080/20469047.2018.1535871

DO - 10.1080/20469047.2018.1535871

M3 - Journal article

C2 - 30382002

VL - 39

SP - 95

EP - 103

JO - Paediatrics and international child health

JF - Paediatrics and international child health

SN - 2046-9047

IS - 2

ER -

ID: 204465619