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Tkanespetsifichnoe metilirovanie spetsifichnykh dlia cheloveka dlinnykh kontsevykh povtorov éndogennykh retrovirusov

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 5; see also http: // www.maik.ru.

OriginalsprogRussisk
TidsskriftBioorganicheskaya Khimiya
Vol/bind30
Udgave nummer5
Sider (fra-til)493-8
Antal sider6
ISSN0132-3423
StatusUdgivet - 26 nov. 2004
Eksternt udgivetJa

    Forskningsområder

  • 3',5'-Cyclic-AMP Phosphodiesterases/genetics, Cyclic Nucleotide Phosphodiesterases, Type 4, DNA Methylation, Deoxyribonuclease HpaII/genetics, Endogenous Retroviruses/genetics, Gene Expression Regulation, Gene Order, Humans, Liver/physiology, Lung/physiology, Lymph Nodes/physiology, NADH Dehydrogenase, Organ Specificity, Proteins/genetics, Terminal Repeat Sequences

ID: 199462113