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Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle

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Standard

Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle. / Kjeldsen, K; Richter, Erik A.; Galbo, H; Lortie, G; Clausen, T.

I: Biochimica et Biophysica Acta - General Subjects, Bind 860, Nr. 3, 1986, s. 708-712.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Kjeldsen, K, Richter, EA, Galbo, H, Lortie, G & Clausen, T 1986, 'Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle', Biochimica et Biophysica Acta - General Subjects, bind 860, nr. 3, s. 708-712.

APA

Kjeldsen, K., Richter, E. A., Galbo, H., Lortie, G., & Clausen, T. (1986). Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle. Biochimica et Biophysica Acta - General Subjects, 860(3), 708-712.

Vancouver

Kjeldsen K, Richter EA, Galbo H, Lortie G, Clausen T. Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle. Biochimica et Biophysica Acta - General Subjects. 1986;860(3):708-712.

Author

Kjeldsen, K ; Richter, Erik A. ; Galbo, H ; Lortie, G ; Clausen, T. / Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle. I: Biochimica et Biophysica Acta - General Subjects. 1986 ; Bind 860, Nr. 3. s. 708-712.

Bibtex

@article{6559ce358d284fa9861e34fcf70bc452,
title = "Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle",
abstract = "Exercise is associated with a net loss of K+ from the working muscles and an increased plasma K+ concentration, indicating that the capacity for intracellular reaccumulation of K+ is exceeded. Training reduces the exercise-induced rise in plasma K+, and an increased plasma [K+] may interfere with physical performance. Since the clearing of K+ from the extracellular space depends on the capacity for active K+ uptake in skeletal muscle, the effects of training and inactivity on the total concentration of (Na+ + K+)-ATPase was determined. Following 6 weeks of swim training, the concentration of [3H]ouabain-binding sites in rat hindlimb muscles was up to 46{\%} (P less than 0.001) higher than in those obtained from age-matched controls. Whereas muscle Na+, K+ contents remained unchanged, the concentration of citrate synthase increased by up to 76{\%} (P less than 0.001). Training induced no change in the [3H]ouabain-binding-site concentration in the diaphragm, but in the heart ventricles, the K+-dependent 3-O-methylfluorescein phosphatase activity increased by 20{\%} (P less than 0.001). Muscle inactivity induced by denervation, plaster immobilisation or tenotomy reduced the [3H]ouabain-binding-site concentration by 20-30{\%} (P less than 0.02-0.001) within 1 week. In conclusion, training leads to a significant and reversible rise in the concentration of (Na+ + K+)-ATPase in muscle cells. This may be of importance for the beneficial effects on physical performance by improving the maximum capacity for K+ clearance.",
keywords = "Animals, Female, Muscles, Ouabain, Physical Exertion, Potassium, Rats, Rats, Inbred Strains, Receptors, Drug, Sodium-Potassium-Exchanging ATPase",
author = "K Kjeldsen and Richter, {Erik A.} and H Galbo and G Lortie and T Clausen",
year = "1986",
language = "English",
volume = "860",
pages = "708--712",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Training increases the concentration of [3H]ouabain-binding sites in rat skeletal muscle

AU - Kjeldsen, K

AU - Richter, Erik A.

AU - Galbo, H

AU - Lortie, G

AU - Clausen, T

PY - 1986

Y1 - 1986

N2 - Exercise is associated with a net loss of K+ from the working muscles and an increased plasma K+ concentration, indicating that the capacity for intracellular reaccumulation of K+ is exceeded. Training reduces the exercise-induced rise in plasma K+, and an increased plasma [K+] may interfere with physical performance. Since the clearing of K+ from the extracellular space depends on the capacity for active K+ uptake in skeletal muscle, the effects of training and inactivity on the total concentration of (Na+ + K+)-ATPase was determined. Following 6 weeks of swim training, the concentration of [3H]ouabain-binding sites in rat hindlimb muscles was up to 46% (P less than 0.001) higher than in those obtained from age-matched controls. Whereas muscle Na+, K+ contents remained unchanged, the concentration of citrate synthase increased by up to 76% (P less than 0.001). Training induced no change in the [3H]ouabain-binding-site concentration in the diaphragm, but in the heart ventricles, the K+-dependent 3-O-methylfluorescein phosphatase activity increased by 20% (P less than 0.001). Muscle inactivity induced by denervation, plaster immobilisation or tenotomy reduced the [3H]ouabain-binding-site concentration by 20-30% (P less than 0.02-0.001) within 1 week. In conclusion, training leads to a significant and reversible rise in the concentration of (Na+ + K+)-ATPase in muscle cells. This may be of importance for the beneficial effects on physical performance by improving the maximum capacity for K+ clearance.

AB - Exercise is associated with a net loss of K+ from the working muscles and an increased plasma K+ concentration, indicating that the capacity for intracellular reaccumulation of K+ is exceeded. Training reduces the exercise-induced rise in plasma K+, and an increased plasma [K+] may interfere with physical performance. Since the clearing of K+ from the extracellular space depends on the capacity for active K+ uptake in skeletal muscle, the effects of training and inactivity on the total concentration of (Na+ + K+)-ATPase was determined. Following 6 weeks of swim training, the concentration of [3H]ouabain-binding sites in rat hindlimb muscles was up to 46% (P less than 0.001) higher than in those obtained from age-matched controls. Whereas muscle Na+, K+ contents remained unchanged, the concentration of citrate synthase increased by up to 76% (P less than 0.001). Training induced no change in the [3H]ouabain-binding-site concentration in the diaphragm, but in the heart ventricles, the K+-dependent 3-O-methylfluorescein phosphatase activity increased by 20% (P less than 0.001). Muscle inactivity induced by denervation, plaster immobilisation or tenotomy reduced the [3H]ouabain-binding-site concentration by 20-30% (P less than 0.02-0.001) within 1 week. In conclusion, training leads to a significant and reversible rise in the concentration of (Na+ + K+)-ATPase in muscle cells. This may be of importance for the beneficial effects on physical performance by improving the maximum capacity for K+ clearance.

KW - Animals

KW - Female

KW - Muscles

KW - Ouabain

KW - Physical Exertion

KW - Potassium

KW - Rats

KW - Rats, Inbred Strains

KW - Receptors, Drug

KW - Sodium-Potassium-Exchanging ATPase

M3 - Journal article

C2 - 3017429

VL - 860

SP - 708

EP - 712

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 3

ER -

ID: 154758076