Forskning ved Københavns Universitet - Københavns Universitet

Forside

Translation attenuation mechanism in unfolded protein response

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

OriginalsprogEngelsk
TitelEvolution from Cellular to Social Scales
RedaktørerArne Skjeltorp, Arne Skjeltorp, Alexander Belushkin
Antal sider8
Publikationsdato1 dec. 2008
Sider83-90
ISBN (Trykt)9781402087608
DOI
StatusUdgivet - 1 dec. 2008
NavnNATO Science for Peace and Security Series B: Physics and Biophysics
ISSN1874-6500

ID: 229440002