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Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut

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By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
OriginalsprogEngelsk
TidsskriftF E B S Letters
Vol/bind211
Udgave nummer2
Sider (fra-til)169-74
Antal sider6
ISSN0014-5793
StatusUdgivet - 1987

ID: 44293803