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Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon

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Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon. / Rumessen, Jüri Johs.; Vanderwinden, Jean-Marie; Rasmussen, Helle; Hansen, Alastair; Horn, Thomas; Rumessen, Jüri Johannes; Vanderwinden, Jean-Marie; Rasmussen, Helle; Hansen, Alastair; Horn, Thomas.

I: Cell and Tissue Research, Bind 337, Nr. 2, 01.08.2009, s. 197-212.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Rumessen, JJ, Vanderwinden, J-M, Rasmussen, H, Hansen, A, Horn, T, Rumessen, JJ, Vanderwinden, J-M, Rasmussen, H, Hansen, A & Horn, T 2009, 'Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon', Cell and Tissue Research, bind 337, nr. 2, s. 197-212. https://doi.org/10.1007/s00441-009-0818-6, https://doi.org/10.1007/s00441-009-0818-6

APA

Rumessen, J. J., Vanderwinden, J-M., Rasmussen, H., Hansen, A., Horn, T., Rumessen, J. J., ... Horn, T. (2009). Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon. Cell and Tissue Research, 337(2), 197-212. https://doi.org/10.1007/s00441-009-0818-6, https://doi.org/10.1007/s00441-009-0818-6

Vancouver

Rumessen JJ, Vanderwinden J-M, Rasmussen H, Hansen A, Horn T, Rumessen JJ o.a. Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon. Cell and Tissue Research. 2009 aug 1;337(2):197-212. https://doi.org/10.1007/s00441-009-0818-6, https://doi.org/10.1007/s00441-009-0818-6

Author

Rumessen, Jüri Johs. ; Vanderwinden, Jean-Marie ; Rasmussen, Helle ; Hansen, Alastair ; Horn, Thomas ; Rumessen, Jüri Johannes ; Vanderwinden, Jean-Marie ; Rasmussen, Helle ; Hansen, Alastair ; Horn, Thomas. / Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon. I: Cell and Tissue Research. 2009 ; Bind 337, Nr. 2. s. 197-212.

Bibtex

@article{f94078904b9011df928f000ea68e967b,
title = "Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon",
abstract = "The role of the interstitial cells of Cajal (ICC) associated with the myenteric plexus (ICC-MP) as regulators of the motility of the colonic external muscle remains unclear. Ultrastructural studies of myenteric interstitial cells are lacking in human colon. We therefore characterized the distinctive ultrastructure of these cells in the myenteric region of the colon by transmission electron microscopy of the region between the main muscle layers in all parts of the colon in unaffected areas of resected specimens from nine adult human patients. ICC-MP were similar in various colonic regions and had myoid features such as scattered caveolae, prominent intermediate filaments, and cytoplasmic dense bodies. We found characteristic dense membrane-associated bands with a patchy basal lamina, invaginating cellular protrusions (peg and socket junctions) between ICC and between ICC and muscle cells, and close contacts (<100 nm) between ICC and nerves. No gap junctions were observed. Fibroblast-like cells (FLC) were abundant showing well-developed secretory organelles, including coated vesicles, but lacked prominent intermediate filaments and caveolae. FLC had a patchy basal lamina, and peg and socket junctions were observed between them. Macrophage-like cells frequently occurred in close apposition with FLC and, more seldomly, with ICC-MP. The ultrastructure of ICC and FLC in the myenteric region of the human colon thus differs characteristically, but significant overlaps in the ultrastructure between ICC and FLC might complicate any interpretation in pathological ultrastructural studies of the human colonic muscle layer.",
author = "Rumessen, {J{\"u}ri Johs.} and Jean-Marie Vanderwinden and Helle Rasmussen and Alastair Hansen and Thomas Horn and Rumessen, {J{\"u}ri Johannes} and Jean-Marie Vanderwinden and Helle Rasmussen and Alastair Hansen and Thomas Horn",
note = "Keywords: Colon; Female; Fibroblasts; Humans; Macrophages; Male; Microscopy, Electron, Transmission; Middle Aged; Muscle, Smooth; Myenteric Plexus",
year = "2009",
month = "8",
day = "1",
doi = "10.1007/s00441-009-0818-6",
language = "English",
volume = "337",
pages = "197--212",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Ultrastructure of interstitial cells of Cajal in myenteric plexus of human colon

AU - Rumessen, Jüri Johs.

AU - Vanderwinden, Jean-Marie

AU - Rasmussen, Helle

AU - Hansen, Alastair

AU - Horn, Thomas

AU - Rumessen, Jüri Johannes

AU - Vanderwinden, Jean-Marie

AU - Rasmussen, Helle

AU - Hansen, Alastair

AU - Horn, Thomas

N1 - Keywords: Colon; Female; Fibroblasts; Humans; Macrophages; Male; Microscopy, Electron, Transmission; Middle Aged; Muscle, Smooth; Myenteric Plexus

PY - 2009/8/1

Y1 - 2009/8/1

N2 - The role of the interstitial cells of Cajal (ICC) associated with the myenteric plexus (ICC-MP) as regulators of the motility of the colonic external muscle remains unclear. Ultrastructural studies of myenteric interstitial cells are lacking in human colon. We therefore characterized the distinctive ultrastructure of these cells in the myenteric region of the colon by transmission electron microscopy of the region between the main muscle layers in all parts of the colon in unaffected areas of resected specimens from nine adult human patients. ICC-MP were similar in various colonic regions and had myoid features such as scattered caveolae, prominent intermediate filaments, and cytoplasmic dense bodies. We found characteristic dense membrane-associated bands with a patchy basal lamina, invaginating cellular protrusions (peg and socket junctions) between ICC and between ICC and muscle cells, and close contacts (<100 nm) between ICC and nerves. No gap junctions were observed. Fibroblast-like cells (FLC) were abundant showing well-developed secretory organelles, including coated vesicles, but lacked prominent intermediate filaments and caveolae. FLC had a patchy basal lamina, and peg and socket junctions were observed between them. Macrophage-like cells frequently occurred in close apposition with FLC and, more seldomly, with ICC-MP. The ultrastructure of ICC and FLC in the myenteric region of the human colon thus differs characteristically, but significant overlaps in the ultrastructure between ICC and FLC might complicate any interpretation in pathological ultrastructural studies of the human colonic muscle layer.

AB - The role of the interstitial cells of Cajal (ICC) associated with the myenteric plexus (ICC-MP) as regulators of the motility of the colonic external muscle remains unclear. Ultrastructural studies of myenteric interstitial cells are lacking in human colon. We therefore characterized the distinctive ultrastructure of these cells in the myenteric region of the colon by transmission electron microscopy of the region between the main muscle layers in all parts of the colon in unaffected areas of resected specimens from nine adult human patients. ICC-MP were similar in various colonic regions and had myoid features such as scattered caveolae, prominent intermediate filaments, and cytoplasmic dense bodies. We found characteristic dense membrane-associated bands with a patchy basal lamina, invaginating cellular protrusions (peg and socket junctions) between ICC and between ICC and muscle cells, and close contacts (<100 nm) between ICC and nerves. No gap junctions were observed. Fibroblast-like cells (FLC) were abundant showing well-developed secretory organelles, including coated vesicles, but lacked prominent intermediate filaments and caveolae. FLC had a patchy basal lamina, and peg and socket junctions were observed between them. Macrophage-like cells frequently occurred in close apposition with FLC and, more seldomly, with ICC-MP. The ultrastructure of ICC and FLC in the myenteric region of the human colon thus differs characteristically, but significant overlaps in the ultrastructure between ICC and FLC might complicate any interpretation in pathological ultrastructural studies of the human colonic muscle layer.

U2 - 10.1007/s00441-009-0818-6

DO - 10.1007/s00441-009-0818-6

M3 - Journal article

C2 - 19506909

VL - 337

SP - 197

EP - 212

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 2

ER -

ID: 19345271