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Uncoupling of cerebral blood flow and metabolism after single episode of cortical spreading depression in the rat brain

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

The present study was undertaken to evaluate whether the persistent hypoperfusion following cortical spreading depression (CSD) in rat brain was accompanied by alterations of regional cortical glucose consumption (rCGU). rCGU was measured using 2-deoxy-[14C]glucose and autoradiography at 15-60 min after single CSD episodes. rCGU did not differ in cortical regions invaded by CSD as compared to the contralateral side and to sham-treated rats. The results suggested impairment of the metabolism-flow couple after CSD.

OriginalsprogEngelsk
TidsskriftBrain Research
Vol/bind370
Udgave nummer2
Sider (fra-til)405-408
Antal sider4
ISSN0006-8993
DOI
StatusUdgivet - 9 apr. 1986

ID: 201457482