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vanO, a new glycopeptide resistance operon in environmental Rhodococcus equi isolates

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We describe sequence and gene organization of a new glycopeptide resistance operon (vanO) in Rhodococcus equi from soil. The vanO operon has low homology to enterococccal van operons and harbors a vanHOX cluster transcribed in opposite direction to the vanS-vanR regulatory system and comprised between three open reading frames with unknown function. This finding has clinical interest since glycopeptides are used to treat R. equi infections and resistance has been reported in clinical isolates.
OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind58
Udgave nummer3
Sider (fra-til)1768-1770
Antal sider3
ISSN0066-4804
DOI
StatusUdgivet - 2014

ID: 94069068