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Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population

Publikation: Bidrag til tidsskriftTidsskriftartikel

  • S K Hansen
  • C S Rose
  • C Glümer
  • T Drivsholm
  • K Borch-Johnsen
  • T Jørgensen
  • O Pedersen
  • T Hansen
The hepatocyte nuclear factor (HNF)-4alpha is an orphan nuclear receptor, which plays crucial roles in regulating hepatic gluconeogenesis and insulin secretion. The gene encoding HNF-4alpha (HNF4A) is located on chromosome 20q12-q13 in a region that in several studies has shown linkage with type 2 diabetes. Recently, two independent studies identified single nucleotide polymorphisms (SNPs) in a 90-kb region spanning HNF4A, which showed strong association with type 2 diabetes in the Finnish and Ashkenazi Jewish populations. In an attempt to replicate and extend these findings, we selected four SNPs in the same HNF4A region, which in the Finnish and Ashkenazi Jewish populations were associated with type 2 diabetes, and examined their relationships with type 2 diabetes and prediabetic phenotypes in the Danish Caucasian population.
OriginalsprogEngelsk
TidsskriftDiabetologia
Vol/bind48
Udgave nummer3
Sider (fra-til)452-8
Antal sider7
ISSN0012-186X
DOI
StatusUdgivet - 1 mar. 2005

ID: 33029460