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Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population

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Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population. / Hansen, S K; Rose, C S; Glümer, C; Drivsholm, T; Borch-Johnsen, K; Jørgensen, T; Pedersen, O; Hansen, T.

I: Diabetologia, Bind 48, Nr. 3, 01.03.2005, s. 452-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hansen, SK, Rose, CS, Glümer, C, Drivsholm, T, Borch-Johnsen, K, Jørgensen, T, Pedersen, O & Hansen, T 2005, 'Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population', Diabetologia, bind 48, nr. 3, s. 452-8. https://doi.org/10.1007/s00125-005-1671-0

APA

Hansen, S. K., Rose, C. S., Glümer, C., Drivsholm, T., Borch-Johnsen, K., Jørgensen, T., ... Hansen, T. (2005). Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population. Diabetologia, 48(3), 452-8. https://doi.org/10.1007/s00125-005-1671-0

Vancouver

Hansen SK, Rose CS, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T o.a. Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population. Diabetologia. 2005 mar 1;48(3):452-8. https://doi.org/10.1007/s00125-005-1671-0

Author

Hansen, S K ; Rose, C S ; Glümer, C ; Drivsholm, T ; Borch-Johnsen, K ; Jørgensen, T ; Pedersen, O ; Hansen, T. / Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population. I: Diabetologia. 2005 ; Bind 48, Nr. 3. s. 452-8.

Bibtex

@article{8aad787cd83740e68b28803d8390f8f8,
title = "Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population",
abstract = "The hepatocyte nuclear factor (HNF)-4alpha is an orphan nuclear receptor, which plays crucial roles in regulating hepatic gluconeogenesis and insulin secretion. The gene encoding HNF-4alpha (HNF4A) is located on chromosome 20q12-q13 in a region that in several studies has shown linkage with type 2 diabetes. Recently, two independent studies identified single nucleotide polymorphisms (SNPs) in a 90-kb region spanning HNF4A, which showed strong association with type 2 diabetes in the Finnish and Ashkenazi Jewish populations. In an attempt to replicate and extend these findings, we selected four SNPs in the same HNF4A region, which in the Finnish and Ashkenazi Jewish populations were associated with type 2 diabetes, and examined their relationships with type 2 diabetes and prediabetic phenotypes in the Danish Caucasian population.",
author = "Hansen, {S K} and Rose, {C S} and C Gl{\"u}mer and T Drivsholm and K Borch-Johnsen and T J{\o}rgensen and O Pedersen and T Hansen",
year = "2005",
month = "3",
day = "1",
doi = "10.1007/s00125-005-1671-0",
language = "English",
volume = "48",
pages = "452--8",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population

AU - Hansen, S K

AU - Rose, C S

AU - Glümer, C

AU - Drivsholm, T

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Pedersen, O

AU - Hansen, T

PY - 2005/3/1

Y1 - 2005/3/1

N2 - The hepatocyte nuclear factor (HNF)-4alpha is an orphan nuclear receptor, which plays crucial roles in regulating hepatic gluconeogenesis and insulin secretion. The gene encoding HNF-4alpha (HNF4A) is located on chromosome 20q12-q13 in a region that in several studies has shown linkage with type 2 diabetes. Recently, two independent studies identified single nucleotide polymorphisms (SNPs) in a 90-kb region spanning HNF4A, which showed strong association with type 2 diabetes in the Finnish and Ashkenazi Jewish populations. In an attempt to replicate and extend these findings, we selected four SNPs in the same HNF4A region, which in the Finnish and Ashkenazi Jewish populations were associated with type 2 diabetes, and examined their relationships with type 2 diabetes and prediabetic phenotypes in the Danish Caucasian population.

AB - The hepatocyte nuclear factor (HNF)-4alpha is an orphan nuclear receptor, which plays crucial roles in regulating hepatic gluconeogenesis and insulin secretion. The gene encoding HNF-4alpha (HNF4A) is located on chromosome 20q12-q13 in a region that in several studies has shown linkage with type 2 diabetes. Recently, two independent studies identified single nucleotide polymorphisms (SNPs) in a 90-kb region spanning HNF4A, which showed strong association with type 2 diabetes in the Finnish and Ashkenazi Jewish populations. In an attempt to replicate and extend these findings, we selected four SNPs in the same HNF4A region, which in the Finnish and Ashkenazi Jewish populations were associated with type 2 diabetes, and examined their relationships with type 2 diabetes and prediabetic phenotypes in the Danish Caucasian population.

U2 - 10.1007/s00125-005-1671-0

DO - 10.1007/s00125-005-1671-0

M3 - Journal article

C2 - 15735891

VL - 48

SP - 452

EP - 458

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 3

ER -

ID: 33029460