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Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb

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Standard

Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. / Colquhoun, E Q; Hettiarachchi, M; Ye, J M; Richter, Erik A.; Hniat, A J; Rattigan, S; Clark, M G.

I: Life Sciences, Bind 43, Nr. 21, 1988, s. 1747-1754.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Colquhoun, EQ, Hettiarachchi, M, Ye, JM, Richter, EA, Hniat, AJ, Rattigan, S & Clark, MG 1988, 'Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb', Life Sciences, bind 43, nr. 21, s. 1747-1754.

APA

Colquhoun, E. Q., Hettiarachchi, M., Ye, J. M., Richter, E. A., Hniat, A. J., Rattigan, S., & Clark, M. G. (1988). Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. Life Sciences, 43(21), 1747-1754.

Vancouver

Colquhoun EQ, Hettiarachchi M, Ye JM, Richter EA, Hniat AJ, Rattigan S o.a. Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. Life Sciences. 1988;43(21):1747-1754.

Author

Colquhoun, E Q ; Hettiarachchi, M ; Ye, J M ; Richter, Erik A. ; Hniat, A J ; Rattigan, S ; Clark, M G. / Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb. I: Life Sciences. 1988 ; Bind 43, Nr. 21. s. 1747-1754.

Bibtex

@article{98d21529136e42638250047b712ebb7c,
title = "Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb",
abstract = "Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb. The increase due to each agent approached 70% of the basal rate, and was greater than that produced by a maximal concentration of norepinephrine. Half-maximal stimulation occurred at 60 pM vasopressin, 0.5 nM angiotensin II and 10 nM norepinephrine. Angiotensins I and III were less potent than angiotensin II. For each agent, the dose-dependent increase in oxygen uptake coincided with a dose-dependent increase in perfusion pressure. The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside. Nitroprusside also inhibited flow-induced increases in hindlimb oxygen uptake and perfusion pressure. The findings indicate a key role for the vascular system in the control of hindlimb oxygen uptake.",
keywords = "Angiotensin I, Angiotensin II, Angiotensin III, Animals, Arginine Vasopressin, Hindlimb, Male, Nitroprusside, Norepinephrine, Oxygen, Oxygen Consumption, Phentolamine, Propranolol, Rats, Rats, Inbred Strains, Reference Values",
author = "Colquhoun, {E Q} and M Hettiarachchi and Ye, {J M} and Richter, {Erik A.} and Hniat, {A J} and S Rattigan and Clark, {M G}",
year = "1988",
language = "English",
volume = "43",
pages = "1747--1754",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier",
number = "21",

}

RIS

TY - JOUR

T1 - Vasopressin and angiotensin II stimulate oxygen uptake in the perfused rat hindlimb

AU - Colquhoun, E Q

AU - Hettiarachchi, M

AU - Ye, J M

AU - Richter, Erik A.

AU - Hniat, A J

AU - Rattigan, S

AU - Clark, M G

PY - 1988

Y1 - 1988

N2 - Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb. The increase due to each agent approached 70% of the basal rate, and was greater than that produced by a maximal concentration of norepinephrine. Half-maximal stimulation occurred at 60 pM vasopressin, 0.5 nM angiotensin II and 10 nM norepinephrine. Angiotensins I and III were less potent than angiotensin II. For each agent, the dose-dependent increase in oxygen uptake coincided with a dose-dependent increase in perfusion pressure. The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside. Nitroprusside also inhibited flow-induced increases in hindlimb oxygen uptake and perfusion pressure. The findings indicate a key role for the vascular system in the control of hindlimb oxygen uptake.

AB - Vasopressin and angiotensin II markedly stimulated oxygen uptake in the perfused rat hindlimb. The increase due to each agent approached 70% of the basal rate, and was greater than that produced by a maximal concentration of norepinephrine. Half-maximal stimulation occurred at 60 pM vasopressin, 0.5 nM angiotensin II and 10 nM norepinephrine. Angiotensins I and III were less potent than angiotensin II. For each agent, the dose-dependent increase in oxygen uptake coincided with a dose-dependent increase in perfusion pressure. The effects of both vasopressin and angiotensin to increase oxygen uptake and pressure were not inhibited by either phentolamine, propranolol or a combination of the two, but were completely inhibited by the vasodilator, nitroprusside. Nitroprusside also inhibited flow-induced increases in hindlimb oxygen uptake and perfusion pressure. The findings indicate a key role for the vascular system in the control of hindlimb oxygen uptake.

KW - Angiotensin I

KW - Angiotensin II

KW - Angiotensin III

KW - Animals

KW - Arginine Vasopressin

KW - Hindlimb

KW - Male

KW - Nitroprusside

KW - Norepinephrine

KW - Oxygen

KW - Oxygen Consumption

KW - Phentolamine

KW - Propranolol

KW - Rats

KW - Rats, Inbred Strains

KW - Reference Values

M3 - Journal article

C2 - 3193858

VL - 43

SP - 1747

EP - 1754

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 21

ER -

ID: 154757796