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Veto cell suppression mechanisms in the prevention of allograft rejection

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  • I M Jacobsen
  • Mogens Helweg Claesson
Substantial evidence has accumulated to suggest that in the near future implementation of the veto-cell-suppressor concept in the treatment of kidney allograft recipients might lead to the establishment of life-long specific allograft tolerance in the absence of further immunosuppressive therapy. Veto suppression prevents the generation of antigen-specific T-helper and cytotoxic T lymphocytes in vitro provided that the T-lymphocyte precursors specifically recognize antigenic peptides associated with the major histocompatibility complex molecules class II and class I, respectively, expressed on the surface of the veto-active cell. Data from a large number of experimental and clinical studies strongly indicate that veto-active cells function in vivo and are capable of preventing allograft rejection. Thus, donor-cell-mediated veto activity is the most likely explanation for the well-known graft tolerizing effect of pretransplant donor blood transfusions in kidney graft recipients. A prerequisite for a veto-active environment in vivo is the establishment of lymphoid microchimerism, in which veto-active donor and recipient cells mutually downregulate potential alloaggression.
OriginalsprogEngelsk
TidsskriftActa Pathologica Microbiologica et Immunologica Scandinavica
Vol/bind106
Udgave nummer3
Sider (fra-til)345-53
Antal sider9
ISSN0903-4641
StatusUdgivet - 1 mar. 1998

ID: 213527