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Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis: Distribution and Changes during Adalimumab Treatment

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis : Distribution and Changes during Adalimumab Treatment. / Krabbe, Simon; Eshed, Iris; Sorensen, Inge Juul; Jensen, Bente; Moller, Jakob M.; Balding, Lone; Madsen, Ole Rintek; Pedersen, Susanne Juhl; Ostergaard, Mikkel.

I: Journal of Rheumatology, Bind 47, Nr. 1, 2020, s. 50-58.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Krabbe, S, Eshed, I, Sorensen, IJ, Jensen, B, Moller, JM, Balding, L, Madsen, OR, Pedersen, SJ & Ostergaard, M 2020, 'Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis: Distribution and Changes during Adalimumab Treatment', Journal of Rheumatology, bind 47, nr. 1, s. 50-58. https://doi.org/10.3899/jrheum.181159

APA

Krabbe, S., Eshed, I., Sorensen, I. J., Jensen, B., Moller, J. M., Balding, L., Madsen, O. R., Pedersen, S. J., & Ostergaard, M. (2020). Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis: Distribution and Changes during Adalimumab Treatment. Journal of Rheumatology, 47(1), 50-58. https://doi.org/10.3899/jrheum.181159

Vancouver

Krabbe S, Eshed I, Sorensen IJ, Jensen B, Moller JM, Balding L o.a. Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis: Distribution and Changes during Adalimumab Treatment. Journal of Rheumatology. 2020;47(1):50-58. https://doi.org/10.3899/jrheum.181159

Author

Krabbe, Simon ; Eshed, Iris ; Sorensen, Inge Juul ; Jensen, Bente ; Moller, Jakob M. ; Balding, Lone ; Madsen, Ole Rintek ; Pedersen, Susanne Juhl ; Ostergaard, Mikkel. / Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis : Distribution and Changes during Adalimumab Treatment. I: Journal of Rheumatology. 2020 ; Bind 47, Nr. 1. s. 50-58.

Bibtex

@article{5e513a1ef1fb4c42a2c3d505619f7f28,
title = "Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis: Distribution and Changes during Adalimumab Treatment",
abstract = "Objective. To investigate the distribution of whole-body magnetic resonance imaging (WB-MRI) inflammatory lesions of peripheral joints and entheses, and their response to adalimumab (ADA) treatment and agreement with clinical measures of disease activity in patients with axial spondyloarthritis (axSpA). Methods. Explorative analysis of an investigator-initiated randomized controlled trial of ADA. WB-MRI was performed at weeks 0, 6, 24, and 48. Detailed analyses of WB-MRI lesions in peripheral joints and entheses were performed, including agreement with clinical measures of disease activity. Results. WB-MRI inflammatory lesions were most frequently observed in the acromioclavicular, metatarsophalangeal, and wrist joints (> 10% of joints), and at the greater trochanter, calcaneal insertion of the Achilles tendon, and ischial tuberosity (> 15% of entheses). Inflammation resolved in ≥ 2/3 of involved sternoclavicular, metacarpophalangeal, first carpometacarpal, hip, and tarsometatarsal joints, and pubic symphyses and medial femoral condyles. In contrast, inflammation resolved in ≤ 1/6 of involved acromioclavicular joints, knee joints, and supraspinatus tendon insertions at humerus. Tenderness of joints and entheses agreed poorly with WB-MRI inflammation (κ < 0.40). Joint tenderness resolved more frequently in MRI-positive than MRI-negative joints (8/13, 62% vs 9/34, 26%) after 6 weeks of active treatment. Conclusion. Inflammatory lesions of peripheral joints and entheses in patients with predominantly axSpA, and changes therein, can be mapped using WB-MRI, and it may contribute to differentiate between inflammatory and noninflammatory joint tenderness.",
keywords = "INFLAMMATION, MAGNETIC RESONANCE IMAGING, OUTCOME ASSESSMENT SPONDYLOARTHROPATHY",
author = "Simon Krabbe and Iris Eshed and Sorensen, {Inge Juul} and Bente Jensen and Moller, {Jakob M.} and Lone Balding and Madsen, {Ole Rintek} and Pedersen, {Susanne Juhl} and Mikkel Ostergaard",
year = "2020",
doi = "10.3899/jrheum.181159",
language = "English",
volume = "47",
pages = "50--58",
journal = "Journal of Rheumatology",
issn = "0315-162X",
publisher = "Journal of Rheumatology Publishing Co. Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Whole-body Magnetic Resonance Imaging Inflammation in Peripheral Joints and Entheses in Axial Spondyloarthritis

T2 - Distribution and Changes during Adalimumab Treatment

AU - Krabbe, Simon

AU - Eshed, Iris

AU - Sorensen, Inge Juul

AU - Jensen, Bente

AU - Moller, Jakob M.

AU - Balding, Lone

AU - Madsen, Ole Rintek

AU - Pedersen, Susanne Juhl

AU - Ostergaard, Mikkel

PY - 2020

Y1 - 2020

N2 - Objective. To investigate the distribution of whole-body magnetic resonance imaging (WB-MRI) inflammatory lesions of peripheral joints and entheses, and their response to adalimumab (ADA) treatment and agreement with clinical measures of disease activity in patients with axial spondyloarthritis (axSpA). Methods. Explorative analysis of an investigator-initiated randomized controlled trial of ADA. WB-MRI was performed at weeks 0, 6, 24, and 48. Detailed analyses of WB-MRI lesions in peripheral joints and entheses were performed, including agreement with clinical measures of disease activity. Results. WB-MRI inflammatory lesions were most frequently observed in the acromioclavicular, metatarsophalangeal, and wrist joints (> 10% of joints), and at the greater trochanter, calcaneal insertion of the Achilles tendon, and ischial tuberosity (> 15% of entheses). Inflammation resolved in ≥ 2/3 of involved sternoclavicular, metacarpophalangeal, first carpometacarpal, hip, and tarsometatarsal joints, and pubic symphyses and medial femoral condyles. In contrast, inflammation resolved in ≤ 1/6 of involved acromioclavicular joints, knee joints, and supraspinatus tendon insertions at humerus. Tenderness of joints and entheses agreed poorly with WB-MRI inflammation (κ < 0.40). Joint tenderness resolved more frequently in MRI-positive than MRI-negative joints (8/13, 62% vs 9/34, 26%) after 6 weeks of active treatment. Conclusion. Inflammatory lesions of peripheral joints and entheses in patients with predominantly axSpA, and changes therein, can be mapped using WB-MRI, and it may contribute to differentiate between inflammatory and noninflammatory joint tenderness.

AB - Objective. To investigate the distribution of whole-body magnetic resonance imaging (WB-MRI) inflammatory lesions of peripheral joints and entheses, and their response to adalimumab (ADA) treatment and agreement with clinical measures of disease activity in patients with axial spondyloarthritis (axSpA). Methods. Explorative analysis of an investigator-initiated randomized controlled trial of ADA. WB-MRI was performed at weeks 0, 6, 24, and 48. Detailed analyses of WB-MRI lesions in peripheral joints and entheses were performed, including agreement with clinical measures of disease activity. Results. WB-MRI inflammatory lesions were most frequently observed in the acromioclavicular, metatarsophalangeal, and wrist joints (> 10% of joints), and at the greater trochanter, calcaneal insertion of the Achilles tendon, and ischial tuberosity (> 15% of entheses). Inflammation resolved in ≥ 2/3 of involved sternoclavicular, metacarpophalangeal, first carpometacarpal, hip, and tarsometatarsal joints, and pubic symphyses and medial femoral condyles. In contrast, inflammation resolved in ≤ 1/6 of involved acromioclavicular joints, knee joints, and supraspinatus tendon insertions at humerus. Tenderness of joints and entheses agreed poorly with WB-MRI inflammation (κ < 0.40). Joint tenderness resolved more frequently in MRI-positive than MRI-negative joints (8/13, 62% vs 9/34, 26%) after 6 weeks of active treatment. Conclusion. Inflammatory lesions of peripheral joints and entheses in patients with predominantly axSpA, and changes therein, can be mapped using WB-MRI, and it may contribute to differentiate between inflammatory and noninflammatory joint tenderness.

KW - INFLAMMATION

KW - MAGNETIC RESONANCE IMAGING

KW - OUTCOME ASSESSMENT SPONDYLOARTHROPATHY

U2 - 10.3899/jrheum.181159

DO - 10.3899/jrheum.181159

M3 - Journal article

C2 - 30936290

AN - SCOPUS:85077404079

VL - 47

SP - 50

EP - 58

JO - Journal of Rheumatology

JF - Journal of Rheumatology

SN - 0315-162X

IS - 1

ER -

ID: 238630503