Forskning ved Københavns Universitet - Københavns Universitet

Forside

Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. / Gjedde, A; Caronna, J J; Hindfelt, B; Plum, F.

I: American Journal of Physiology (Consolidated), Bind 229, Nr. 1, 1975, s. 113-8.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gjedde, A, Caronna, JJ, Hindfelt, B & Plum, F 1975, 'Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia.', American Journal of Physiology (Consolidated), bind 229, nr. 1, s. 113-8.

APA

Gjedde, A., Caronna, J. J., Hindfelt, B., & Plum, F. (1975). Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. American Journal of Physiology (Consolidated), 229(1), 113-8.

Vancouver

Gjedde A, Caronna JJ, Hindfelt B, Plum F. Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. American Journal of Physiology (Consolidated). 1975;229(1):113-8.

Author

Gjedde, A ; Caronna, J J ; Hindfelt, B ; Plum, F. / Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. I: American Journal of Physiology (Consolidated). 1975 ; Bind 229, Nr. 1. s. 113-8.

Bibtex

@article{ec6196f0b31411debc73000ea68e967b,
title = "Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia.",
abstract = "The Kety-Schmidt washout technique has been modified to measure whole-brain blood flow and metabolism in the rat. During nitrous oxide anesthesia, 14 rats exhaled (133)Xe, and continuous and simultaneous arterial and cerebral venous samples were drawn from a femoral artery and the transverse sinus of the brain. Extracerebral contamination of the venous sample was minimal, and equilibration of (133)Xe in brain tissue and blood was obtained after 10-24 min of inhalation. Cerebral blood flow was calculated from the total activity of the mechanically integrated arterial and venous samples according to the principle of Scheinberg and Stead. At a mean Paco2 of 40 mmHg, CBF averaged 98 +/- 6 (SEM) ml/100 g-min and CMRO2 averaged 5.4 +/- 0.7 (SEM) ml/100 g-min. CBF changed 2.4% with each millimeter Hg change of Paco2 while CMRO2 changed only insignificantly. The values obtained for CBF are higher than reported for man and large laboratory animals bur reflect the proportionately greater amount of gray matter in the rat brain.",
author = "A Gjedde and Caronna, {J J} and B Hindfelt and F Plum",
year = "1975",
language = "English",
volume = "229",
pages = "113--8",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "1",

}

RIS

TY - JOUR

T1 - Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia.

AU - Gjedde, A

AU - Caronna, J J

AU - Hindfelt, B

AU - Plum, F

PY - 1975

Y1 - 1975

N2 - The Kety-Schmidt washout technique has been modified to measure whole-brain blood flow and metabolism in the rat. During nitrous oxide anesthesia, 14 rats exhaled (133)Xe, and continuous and simultaneous arterial and cerebral venous samples were drawn from a femoral artery and the transverse sinus of the brain. Extracerebral contamination of the venous sample was minimal, and equilibration of (133)Xe in brain tissue and blood was obtained after 10-24 min of inhalation. Cerebral blood flow was calculated from the total activity of the mechanically integrated arterial and venous samples according to the principle of Scheinberg and Stead. At a mean Paco2 of 40 mmHg, CBF averaged 98 +/- 6 (SEM) ml/100 g-min and CMRO2 averaged 5.4 +/- 0.7 (SEM) ml/100 g-min. CBF changed 2.4% with each millimeter Hg change of Paco2 while CMRO2 changed only insignificantly. The values obtained for CBF are higher than reported for man and large laboratory animals bur reflect the proportionately greater amount of gray matter in the rat brain.

AB - The Kety-Schmidt washout technique has been modified to measure whole-brain blood flow and metabolism in the rat. During nitrous oxide anesthesia, 14 rats exhaled (133)Xe, and continuous and simultaneous arterial and cerebral venous samples were drawn from a femoral artery and the transverse sinus of the brain. Extracerebral contamination of the venous sample was minimal, and equilibration of (133)Xe in brain tissue and blood was obtained after 10-24 min of inhalation. Cerebral blood flow was calculated from the total activity of the mechanically integrated arterial and venous samples according to the principle of Scheinberg and Stead. At a mean Paco2 of 40 mmHg, CBF averaged 98 +/- 6 (SEM) ml/100 g-min and CMRO2 averaged 5.4 +/- 0.7 (SEM) ml/100 g-min. CBF changed 2.4% with each millimeter Hg change of Paco2 while CMRO2 changed only insignificantly. The values obtained for CBF are higher than reported for man and large laboratory animals bur reflect the proportionately greater amount of gray matter in the rat brain.

M3 - Journal article

C2 - 1147036

VL - 229

SP - 113

EP - 118

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

SN - 0002-9513

IS - 1

ER -

ID: 14942427