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Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Standard

Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients. / Gøtzsche, P C; Bygbjerg, Ib Christian; Olesen, B; Møller, L H; Salim, Y S; Faber, V.

I: Scandinavian Journal of Infectious Diseases, Bind 20, Nr. 4, 01.01.1988, s. 395-402.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Gøtzsche, PC, Bygbjerg, IC, Olesen, B, Møller, LH, Salim, YS & Faber, V 1988, 'Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients', Scandinavian Journal of Infectious Diseases, bind 20, nr. 4, s. 395-402.

APA

Gøtzsche, P. C., Bygbjerg, I. C., Olesen, B., Møller, L. H., Salim, Y. S., & Faber, V. (1988). Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients. Scandinavian Journal of Infectious Diseases, 20(4), 395-402.

Vancouver

Gøtzsche PC, Bygbjerg IC, Olesen B, Møller LH, Salim YS, Faber V. Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients. Scandinavian Journal of Infectious Diseases. 1988 jan 1;20(4):395-402.

Author

Gøtzsche, P C ; Bygbjerg, Ib Christian ; Olesen, B ; Møller, L H ; Salim, Y S ; Faber, V. / Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients. I: Scandinavian Journal of Infectious Diseases. 1988 ; Bind 20, Nr. 4. s. 395-402.

Bibtex

@article{f109ca1a82564d69bea812d2184dc99b,
title = "Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients",
abstract = "To examine the therapeutic consequences of diagnostic tests for AIDS-related infections, case records from 33 deceased AIDS patients were reviewed; 23 were autopsied. Determination of serum antibody titres was not important. In particular, there was no relation between titres and isolation of cytomegalovirus (CMV); isolation attempts or possibly antigen determination would be better. Samples for CMV isolation were obtained from 31 patients; only 7 were negative. Blood, faeces, and particularly sputum cultures gave a low yield; the number of such examinations could be reduced considerably. However, 4/7 disseminated infections with atypical mycobacteria were only revealed at autopsy, despite numerous cultures in vivo. Liver biopsies were not helpful. Diagnostic procedures for Pneumocystis carinii pneumonia by lung biopsy caused pneumothorax in 3/15 patients; bronchoalveolar lavage or treatment/prophylaxis without diagnosis could be considered. In 8 autopsies, microscopy was suggestive of cerebral toxoplasmosis, but only 1 patient had presented important clinical symptoms. We suggest a schedule with regular microbiologic and parasitic examinations and few antibody tests, but with more antigen tests.",
keywords = "Acquired Immunodeficiency Syndrome, Adult, Animals, Brain Diseases, Cytomegalovirus Infections, Diarrhea, Enzyme-Linked Immunosorbent Assay, Humans, Middle Aged, Opportunistic Infections, Pneumonia, Pneumonia, Pneumocystis, Retrospective Studies, Sepsis, Toxoplasmosis",
author = "G{\o}tzsche, {P C} and Bygbjerg, {Ib Christian} and B Olesen and M{\o}ller, {L H} and Salim, {Y S} and V Faber",
year = "1988",
month = jan,
day = "1",
language = "English",
volume = "20",
pages = "395--402",
journal = "Scandinavian Journal of Infectious Diseases",
issn = "0036-5548",
publisher = "Taylor & Francis",
number = "4",

}

RIS

TY - JOUR

T1 - Yield of diagnostic tests for opportunistic infections in AIDS: a survey of 33 patients

AU - Gøtzsche, P C

AU - Bygbjerg, Ib Christian

AU - Olesen, B

AU - Møller, L H

AU - Salim, Y S

AU - Faber, V

PY - 1988/1/1

Y1 - 1988/1/1

N2 - To examine the therapeutic consequences of diagnostic tests for AIDS-related infections, case records from 33 deceased AIDS patients were reviewed; 23 were autopsied. Determination of serum antibody titres was not important. In particular, there was no relation between titres and isolation of cytomegalovirus (CMV); isolation attempts or possibly antigen determination would be better. Samples for CMV isolation were obtained from 31 patients; only 7 were negative. Blood, faeces, and particularly sputum cultures gave a low yield; the number of such examinations could be reduced considerably. However, 4/7 disseminated infections with atypical mycobacteria were only revealed at autopsy, despite numerous cultures in vivo. Liver biopsies were not helpful. Diagnostic procedures for Pneumocystis carinii pneumonia by lung biopsy caused pneumothorax in 3/15 patients; bronchoalveolar lavage or treatment/prophylaxis without diagnosis could be considered. In 8 autopsies, microscopy was suggestive of cerebral toxoplasmosis, but only 1 patient had presented important clinical symptoms. We suggest a schedule with regular microbiologic and parasitic examinations and few antibody tests, but with more antigen tests.

AB - To examine the therapeutic consequences of diagnostic tests for AIDS-related infections, case records from 33 deceased AIDS patients were reviewed; 23 were autopsied. Determination of serum antibody titres was not important. In particular, there was no relation between titres and isolation of cytomegalovirus (CMV); isolation attempts or possibly antigen determination would be better. Samples for CMV isolation were obtained from 31 patients; only 7 were negative. Blood, faeces, and particularly sputum cultures gave a low yield; the number of such examinations could be reduced considerably. However, 4/7 disseminated infections with atypical mycobacteria were only revealed at autopsy, despite numerous cultures in vivo. Liver biopsies were not helpful. Diagnostic procedures for Pneumocystis carinii pneumonia by lung biopsy caused pneumothorax in 3/15 patients; bronchoalveolar lavage or treatment/prophylaxis without diagnosis could be considered. In 8 autopsies, microscopy was suggestive of cerebral toxoplasmosis, but only 1 patient had presented important clinical symptoms. We suggest a schedule with regular microbiologic and parasitic examinations and few antibody tests, but with more antigen tests.

KW - Acquired Immunodeficiency Syndrome

KW - Adult

KW - Animals

KW - Brain Diseases

KW - Cytomegalovirus Infections

KW - Diarrhea

KW - Enzyme-Linked Immunosorbent Assay

KW - Humans

KW - Middle Aged

KW - Opportunistic Infections

KW - Pneumonia

KW - Pneumonia, Pneumocystis

KW - Retrospective Studies

KW - Sepsis

KW - Toxoplasmosis

M3 - Journal article

C2 - 2848314

VL - 20

SP - 395

EP - 402

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

SN - 0036-5548

IS - 4

ER -

ID: 33891529