Forskning ved Københavns Universitet - Københavns Universitet

Forside
Jens Bukh
Jens Bukh

Professor

  • Virology

    Blegdamsvej 3B, København N, 07 Bygning 7, Building: 07-13-84

    Mobile: +4523418969

  1. 2021
  2. Published

    In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms

    Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, Anette Gleitze & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus

    Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    Characterization of a novel hepatitis C virus genotype 1 subtype from a patient failing 4 weeks of glecaprevir-pibrentasvir treatment

    Pedersen, M. S., Fahnøe, Ulrik, Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, Jens, 2021, In: Microbiology resource announcements. 10, 41, e00755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro

    Zhou, Y., Gammeltoft, Karen Anbro, Galli, Andrea, Offersgaard, A., Fahnøe, Ulrik, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Viruses. 13, 10, 2082.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

    Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

    Fahnøe, Ulrik, Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Thielsen, P., Madsen, Lone Galmstrup, Pedersen, A. G., Schønning, Kristian, Weis, Nina & Bukh, Jens, 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Accepted/In press

    HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

    Pham, Long, Pedersen, M. S., Fahnøe, Ulrik, Fernandez-Antunez, C., Humes, D., Schønning, Kristian, Ramirez Almeida, Santseharay & Bukh, Jens, 2021, (Accepted/In press) In: Gut. 20323585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

    Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, A., Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, Shan, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

    Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

    Zhou, Y., Gilmore, K., Ramirez Almeida, Santseharay, Settels, E., Gammeltoft, Karen Anbro, Pham, Long, Fahnøe, Ulrik, Feng, Shan, Offersgaard, A., Trimpert, J., Bukh, Jens, Osterrieder, K., Gottwein, Judith Margarete & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Accepted/In press

    Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

    Madsen, L. W., Christensen, P. B., Fahnøe, Ulrik, Pedersen, M. S., Bukh, Jens & Øvrehus, A., 2021, (Accepted/In press) In: Liver International.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19

    Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Winckelmann, A. A., Bollerup, S., Mikkelsen, L. S., Sørensen, A. L., Feng, Shan, Fahnøe, Ulrik, Lassauniere, R., Fomsgaard, A., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2021, In: EBioMedicine. 71, 103519.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication

    Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Galli, Andrea, Underwood, Alexander Paul James, Pham, Long, Ryberg, Line Abildgaard, Feng, Shan, Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, Nina, Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection

    Tomlinson, J. E., Wolfisberg, Raphael, Fahnøe, Ulrik, Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, Jens, Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2021, In: Hepatology. 74, 3, p. 1148-1163

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Sars-cov-2 production in a scalable high cell density bioreactor

    Offersgaard, A., Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Van Pham, L., Feng, Shan, Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Vaccines against hepatitis C: A travel into neutralisation space

    Bukh, Jens, 2021, In: Gut. 70, 9, p. 1609-1610 2 p., 323377.

    Research output: Contribution to journalComment/debateResearchpeer-review

  20. Published

    Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

    STOP-HCV Consortium, S. C., 2021, In: Nature Communications. 12, 1, 11 p., 6105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2020
  22. Published

    Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Kokkonos, Konstantinos Georgios, Fossat, Nicolas Julien, Nielsen, L., Holm, C., Hepkema, W. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

    Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2C

    Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y. P. & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.

    Research output: Contribution to journalJournal articleResearchpeer-review

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