Forskning ved Københavns Universitet - Københavns Universitet

Forside
Jens Bukh
Jens Bukh

Professor

  • Virology

    Blegdamsvej 3B, København N, 07 Bygning 7, Building: 07-13-84

    Mobile: +4523418969

  1. 2021
  2. Published

    In vitro Characterization of Fitness and Convalescent Antibody Neutralization of SARS-CoV-2 Cluster 5 Variant Emerging in Mink at Danish Farms

    Lassaunière, R., Fonager, J., Rasmussen, M., Frische, A., Polacek, C., Rasmussen, T. B., Lohse, L., Belsham, Graham John, Underwood, Alexander Paul James, Winckelmann, A. A., Bollerup, S., Bukh, Jens, Weis, Nina, Sækmose, S. G., Aagaard, B., Alfaro-Núñez, A., Mølbak, Kåre, Bøtner, Anette Gleitze & Fomsgaard, A., 2021, In: Frontiers in Microbiology. 12, 9 p., 698944.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    In vitro adaptation and characterization of attenuated hypervariable region 1 swap chimeras of hepatitis C virus

    Olesen, C. H., Augestad, Elias Honerød, Troise, F., Bukh, Jens & Prentø, Jannick, 2021, In: PLOS Pathogens. 17, July, 29 p., e1009720.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published
  5. Published

    Characterization of a novel hepatitis C virus genotype 1 subtype from a patient failing 4 weeks of glecaprevir-pibrentasvir treatment

    Pedersen, M. S., Fahnøe, Ulrik, Madsen, L. W., Christensen, P. B., Øvrehus, A. & Bukh, Jens, 2021, In: Microbiology resource announcements. 10, 41, e00755.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Efficacy of ion-channel inhibitors amantadine, memantine and rimantadine for the treatment of SARS-CoV-2 in vitro

    Zhou, Y., Gammeltoft, Karen Anbro, Galli, Andrea, Offersgaard, A., Fahnøe, Ulrik, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Viruses. 13, 10, 2082.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Functional convergence of a germline-encoded neutralizing antibody response in rhesus macaques immunized with HCV envelope glycoproteins

    Chen, F., Tzarum, N., Lin, X., Giang, E., Velázquez-Moctezuma, R., Augestad, Elias Honerød, Nagy, K., He, L., Hernandez, M., Fouch, M. E., Grinyó, A., Chavez, D., Doranz, B. J., Prentø, Jannick, Stanfield, R. L., Lanford, R., Bukh, Jens, Wilson, I. A., Zhu, J. & Law, M., 2021, In: Immunity. 54, 4, p. 781-796.e4

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome

    Fahnøe, Ulrik, Pedersen, M. S., Sølund, C., Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Thielsen, P., Madsen, Lone Galmstrup, Pedersen, A. G., Schønning, Kristian, Weis, Nina & Bukh, Jens, 2021, In: Journal of Viral Hepatitis. 28, 2, p. 302-316

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Accepted/In press

    HCV genome-wide analysis for development of efficient culture systems and unravelling of antiviral resistance in genotype 4

    Pham, Long, Pedersen, M. S., Fahnøe, Ulrik, Fernandez-Antunez, C., Humes, D., Schønning, Kristian, Ramirez Almeida, Santseharay & Bukh, Jens, 2021, (Accepted/In press) In: Gut. 20323585.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 in Vitro

    Gammeltoft, Karen Anbro, Zhou, Y., Duarte Hernandez, C. R., Galli, Andrea, Offersgaard, A., Costa, Rui, Pham, Long, Fahnøe, Ulrik, Feng, Shan, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Bukh, Jens & Gottwein, Judith Margarete, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 9, e02680-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Hepatitis C virus envelope protein dynamics and the link to hypervariable region 1

    Augestad, Elias Honerød, Bukh, Jens & Prentø, Jannick, 2021, In: Current Opinion in Virology. 50, p. 69-75 7 p.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    In vitro efficacy of artemisinin-based treatments against SARS-CoV-2

    Zhou, Y., Gilmore, K., Ramirez Almeida, Santseharay, Settels, E., Gammeltoft, Karen Anbro, Pham, Long, Fahnøe, Ulrik, Feng, Shan, Offersgaard, A., Trimpert, J., Bukh, Jens, Osterrieder, K., Gottwein, Judith Margarete & Seeberger, P. H., 2021, In: Scientific Reports. 11, 14571.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Accepted/In press

    Inferior cure rate in pilot study of 4-week glecaprevir/pibrentasvir treatment with or without ribavirin of chronic hepatitis C

    Madsen, L. W., Christensen, P. B., Fahnøe, Ulrik, Pedersen, M. S., Bukh, Jens & Øvrehus, A., 2021, (Accepted/In press) In: Liver International.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published
  15. Published

    Neutralisation titres against SARS-CoV-2 are sustained 6 months after onset of symptoms in individuals with mild COVID-19

    Underwood, Alexander Paul James, Sølund, C., Fernandez-Antunez, C., Villadsen, S. L., Winckelmann, A. A., Bollerup, S., Mikkelsen, L. S., Sørensen, A. L., Feng, Shan, Fahnøe, Ulrik, Lassauniere, R., Fomsgaard, A., Ramirez Almeida, Santseharay, Weis, Nina & Bukh, Jens, 2021, In: EBioMedicine. 71, 103519.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Overcoming culture restriction for SARS-CoV-2 in human cells facilitates the screening of compounds inhibiting viral replication

    Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Galli, Andrea, Underwood, Alexander Paul James, Pham, Long, Ryberg, Line Abildgaard, Feng, Shan, Pedersen, M. S., Mikkelsen, L. S., Belouzard, S., Dubuisson, J., Sølund, C., Weis, Nina, Gottwein, Judith Margarete, Fahnøe, Ulrik & Bukh, Jens, 2021, In: Antimicrobial Agents and Chemotherapy. 65, 7, 20 p., e00097-21.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Pathogenesis, miR-122 gene-regulation, and protective immune responses after acute equine hepacivirus infection

    Tomlinson, J. E., Wolfisberg, Raphael, Fahnøe, Ulrik, Patel, R. S., Trivedi, S., Kumar, A., Sharma, H., Nielsen, L., McDonough, S. P., Bukh, Jens, Tennant, B. C., Kapoor, A., Rosenberg, B. R., Rice, C. M., Divers, T. J., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2021, In: Hepatology. 74, 3, p. 1148-1163

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Sars-cov-2 production in a scalable high cell density bioreactor

    Offersgaard, A., Hernandez, C. R. D., Pihl, A. F., Costa, Rui, Venkatesan, N. P., Lin, X., Van Pham, L., Feng, Shan, Fahnøe, Ulrik, Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Reichl, U., Bukh, Jens, Genzel, Y. & Gottwein, Judith Margarete, 2021, In: Vaccines. 9, 7, 706.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Vaccines against hepatitis C: A travel into neutralisation space

    Bukh, Jens, 2021, In: Gut. 70, 9, p. 1609-1610 2 p., 323377.

    Research output: Contribution to journalComment/debateResearchpeer-review

  20. Published

    Viral genome wide association study identifies novel hepatitis C virus polymorphisms associated with sofosbuvir treatment failure

    STOP-HCV Consortium, S. C., 2021, In: Nature Communications. 12, 1, 11 p., 6105.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. 2020
  22. Published

    Evolutionary selection of pestivirus variants with altered or no microRNA dependency

    Kokkonos, Konstantinos Georgios, Fossat, Nicolas Julien, Nielsen, L., Holm, C., Hepkema, W. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 4 Jun 2020, In: Nucleic Acids Research. 48, 10, p. 5555-5571 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    An alternate conformation of HCV E2 neutralizing face as an additional vaccine target

    Tzarum, N., Giang, E., Kadam, R. U., Chen, F., Nagy, K., Augestad, E. H., Velázquez-Moctezuma, R., Keck, Z. Y., Hua, Y., Stanfield, R. L., Dreux, M., Prentø, Jannick, Foung, S. K. H., Bukh, Jens, Wilson, I. A. & Law, M., 2020, In: Science Advances. 6, 30, abb5642.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Analysis of virus population profiles within pigs infected with virulent Classical Swine Fever viruses; evidence for bottlenecks in transmission but absence of tissue specific virus variants

    Johnston, C. M., Fahnøe, Ulrik, Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: Journal of Virology. 94, 19, 20 p., e01119-20.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B-Cell–Based Vaccine Development

    Chen, F., Nagy, K., Chavez, D., Willis, S., McBride, R., Giang, E., Honda, A., Bukh, Jens, Ordoukhanian, P., Zhu, J., Frey, S., Lanford, R. & Law, M., 2020, In: Gastroenterology. 158, 4, p. 1058-1071.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Cell culture studies of the efficacy and barrier to resistance of sofosbuvir-velpatasvir and glecaprevir-pibrentasvir against hepatitis C virus genotypes 2a, 2b, and 2C

    Ramirez Almeida, Santseharay, Fernandez-Antunez, C., Mikkelsen, L. S., Pedersen, J., Li, Y. P. & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 3, e01888.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Development of a downstream process for the production of an inactivated whole hepatitis C virus vaccine

    Lothert, K., Offersgaard, A. F., Pihl, A. F., Mathiesen, C. K., Jensen, T. B., Alzua, G. P., Fahnøe, Ulrik, Bukh, Jens, Gottwein, Judith Margarete & Wolff, M. W., 2020, In: Scientific Reports. 10, 13 p., 16261.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Elimination af hepatitis C-virus i Danmark

    Døssing, A., Røge, B. T., Madsen, Lone Galmstrup, Laursen, A. L., Hansen, J. B., Bukh, Jens & Weis, Nina, 2020, In: Ugeskrift for Laeger. 182, 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Equine pegiviruses cause persistent infection of bone marrow and are not associated with hepatitis

    Tomlinson, J. E., Wolfisberg, Raphael, Fahnøe, Ulrik, Sharma, H., Renshaw, R. W., Nielsen, L., Nishiuchi, E., Holm, C., Dubovi, E., Rosenberg, B. R., Tennant, B. C., Bukh, Jens, Kapoor, A., Divers, T. J., Rice, C. M., Van de Walle, G. R. & Scheel, Troels Kasper Høyer, 2020, In: P L o S Pathogens. 16, 7, 23 p., e1008677.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity

    Augestad, E. H., Castelli, M., Clementi, N., Ströh, L. J., Krey, T., Burioni, R., Mancini, N., Bukh, Jens & Prentø, Jannick, 2020, In: Science Advances. 6, 35, 13 p., eabb5938.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Identification of specific amino acid residues in the border disease virus glycoprotein E2 that modify virus growth in pig cells but not in sheep cells

    Fahnøe, Ulrik, Deng, Y., Davids, N. A., Lohse, L., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2020, In: The Journal of general virology. 101, 11, p. 1170-1181

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Insights into the unique characteristics of hepatitis C virus genotype 3 revealed by development of a robust sub-genomic DBN3a replicon

    Ward, J. C., Bowyer, S., Chen, S., Fernandes Campos, G. R., Ramirez Almeida, Santseharay, Bukh, Jens & Harris, M., 2020, In: The Journal of general virology. 101, 11, p. 1182-1190 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Mutations Identified in the Hepatitis C Virus (HCV) Polymerase of Patients with Chronic HCV Treated with Ribavirin Cause Resistance and Affect Viral Replication Fidelity

    Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Weiland, O., Benfield, Thomas & Bukh, Jens, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 12

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Reflections on the History of HCV: A Posthumous Examination

    Alter, H. J., Farci, P., Bukh, Jens & Purcell, R. H., 2020, In: Clinical Liver Disease. 15, S1, p. S64-S71

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Mejer, N., Galli, Andrea, Ramirez Almeida, Santseharay, Fahnøe, Ulrik, Benfield, Thomas & Bukh, Jens, 2020, In: Virology. 540, p. 132-140 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Specific antibodies induced by immunization with hepatitis B virus-like particles carrying hepatitis C virus envelope glycoprotein 2 epitopes show differential neutralization efficiency

    Czarnota, A., Offersgaard, A., Pihl, A. F., Prentø, Jannick, Bukh, Jens, Gottwein, Judith Margarete, Bieńkowska-Szewczyk, K. & Grzyb, K., 2020, In: Vaccines. 8, 2, 19 p., 294.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. 2019
  38. Published

    Broadly neutralizing antibodies from an individual that naturally cleared multiple hepatitis c virus infections uncover molecular determinants for E2 targeting and vaccine design

    Keck, Z. Y., Pierce, B. G., Lau, P., Lu, J., Wang, Y., Underwood, A., Bull, R. A., Prentø, Jannick, Velázquez-Moctezuma, R., Walker, Melanie Rose, Luciani, F., Guest, J. D., Fauvelle, C., Baumert, T. F., Bukh, Jens, Lloyd, A. R. & Foung, S. K. H., 2019, In: P L o S Pathogens. 15, 5, 28 p., e1007772.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Evolutionary Pathways to Persistence of Highly Fit and Resistant Hepatitis C Virus Protease Inhibitor Escape Variants

    Jensen, S. B., Fahnøe, Ulrik, Pham, Long, Serre, S. B. N., Tang, Q., Ghanem, L., Pedersen, M. S., Ramirez Almeida, Santseharay, Humes, D., Pihl, A. F., Filskov, J., Sølund, C. S., Dietz, J., Fourati, S., Pawlotsky, J. M., Sarrazin, C., Weis, Nina, Schønning, Kristian, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Hepatology. 70, 3, p. 771-787 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Full-length open reading frame amplification of hepatitis C virus

    Fahnøe, Ulrik & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 85-91 7 p. (Methods in Molecular Biology, Vol. 1911).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  41. Published

    Genetic and structural insights into broad neutralization of hepatitis C virus by human VH1-69 antibodies

    Tzarum, N., Giang, E., Kong, L., He, L., Prentø, Jannick, Augestad, E., Hua, Y., Castillo, S., Lauer, G. M., Bukh, Jens, Zhu, J., Wilson, I. A. & Law, M., 2019, In: Science Advances. 5, 1, 12 p., eaav1882.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Genome sequence of an unknown subtype of hepatitis C virus genotype 6: Another piece for the taxonomic puzzle

    Pedersen, M. S., Mollerup, S., Nielsen, L. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2019, In: Microbiology resource announcements. 8, 42, e01030-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    HCV genotype 1-6 NS3 residue 80 substitutions impact protease inhibitor activity and promote viral escape

    Pham, Long, Jensen, S. B., Fahnøe, Ulrik, Pedersen, M. S., Tang, Q., Ghanem, L., Ramirez Almeida, Santseharay, Humes, D., Serre, S. B. N., Schønning, Kristian, Bukh, Jens & Gottwein, Judith Margarete, 2019, In: Journal of Hepatology. 70, 3, p. 388-397

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Filskov, J., Andersen, P., Agger, E. M. & Bukh, Jens, 2019, In: Scientific Reports. 9, 1, 13 p., 14085.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Hepatitis C Virus–Escape Studies for Human Monoclonal Antibody AR4A Reveal Isolate-Specific Resistance and a High Barrier to Resistance

    Velázquez-moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: The Journal of Infectious Diseases. 219, 1, p. 68-79

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Hepatitis C virus escape studies of human antibody AR3a reveal a high barrier to resistance and novel insights on viral antibody evasion mechanisms

    Velázquez-Moctezuma, R., Galli, Andrea, Law, M., Bukh, Jens & Prentø, Jannick, 2019, In: Journal of Virology. 93, 4, 27 p., e0190918.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Hypervariable region 1 and N-linked glycans of hepatitis C regulate virion neutralization by modulating envelope conformations

    Prentø, Jannick, Velázquez-Moctezuma, R., Augestad, E. H., Galli, Andrea, Wang, R., Law, M., Alter, H. & Bukh, Jens, 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 20, p. 10039-10047 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    In vitro neutralization assay using cultured hepatitis C virus

    Prentø, Jannick & Bukh, Jens, 2019, Hepatitis C Virus Protocols. Humana Press, p. 433-439 7 p. (Methods in Molecular Biology, Vol. 1911).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  49. Published

    Replicons of a Rodent Hepatitis C Model Virus Permit Selection of Highly Permissive Cells

    Wolfisberg, Raphael, Holmbeck, Kenn, Nielsen, L., Kapoor, A., Rice, C. M., Bukh, Jens & Scheel, Troels Kasper Høyer, 2019, In: Journal of Virology. 93, 19, 19 p., e00733-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Virus adaptation and selection following challenge of animals vaccinated against classical swine fever virus

    Fahnøe, Ulrik, Pedersen, A. G., Johnston, C. M., Orton, R. J., Höper, D., Beer, M., Bukh, Jens, Belsham, Graham John & Rasmussen, T. B., 2019, In: Viruses. 11, 10, 932.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. 2018
  52. Published

    Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry

    Riva, L., Song, O., Prentø, Jannick, Helle, F., L'homme, L., Gattolliat, C., Vandeputte, A., Feneant, L., Belouzard, S., Baumert, T. F., Asselah, T., Bukh, Jens, Brodin, P., Cocquerel, L., Rouille, Y. & Dubuisson, J., 1 May 2018, In: Journal of Virology. 92, 10, 19 p., e01982-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Efficacy of NS5A Inhibitors Against Hepatitis C Virus Genotypes 1–7 and Escape Variants

    Gottwein, Judith Margarete, Pham, Long, Mikkelsen, L. S., Ghanem, L., Ramirez Almeida, Santseharay, Scheel, Troels Kasper Høyer, Carlsen, T. H. R. & Bukh, Jens, Apr 2018, In: Gastroenterology. 154, 5, p. 1435-1448 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    A near full-length open reading frame next generation sequencing assay for genotyping and identification of resistance-associated variants in hepatitis C virus

    Pedersen, M. S., Fahnøe, Ulrik, Hansen, T. A., Pedersen, A. G., Jenssen, H., Bukh, Jens & Schønning, Kristian, 2018, In: Journal of Clinical Virology. 105, p. 49-56 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Antiviral Effect of Ribavirin against HCV Associated with Increased Frequency of G-to-A and C-to-U Transitions in Infectious Cell Culture Model

    Galli, Andrea, Mens, H., Gottwein, Judith Margarete, Gerstoft, Jan & Bukh, Jens, 2018, In: Scientific Reports. 8, 1, 13 p., 4619.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Critical challenges and emerging opportunities in hepatitis C virus research in an era of potent antiviral therapy: Considerations for scientists and funding agencies

    Bartenschlager, R., Baumert, T. F., Bukh, Jens, Houghton, M., Lemon, S. M., Lindenbach, B. D., Lohmann, V., Moradpour, D., Pietschmann, T., Rice, C. M., Thimme, R. & Wakita, T., 2018, In: Virus Research. 248, p. 53-62 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  57. Published
  58. Published

    Direct acting antiviral treatment of chronic hepatitis C in Denmark: factors associated with and barriers to treatment initiation

    Sølund, C., Hallager, S., Pedersen, M. S., Fahnøe, Ulrik, Ernst, A., Krarup, H. B., Røge, B. T., Christensen, P. B., Laursen, A. L., Gerstoft, Jan, Bélard, E., Madsen, Lone Galmstrup, Schønning, Kristian, Pedersen, A. G., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2018, In: Scandinavian Journal of Gastroenterology. 53, 7, p. 849-856 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models

    Pham, Long, Ramirez Almeida, Santseharay, Gottwein, Judith Margarete, Fahnøe, Ulrik, Li, Y., Pedersen, J. & Bukh, Jens, 2018, In: Gastroenterology. 154, 8, p. 2194-2208.e12

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    High density Huh7.5 cell hollow fiber bioreactor culture for high-yield production of hepatitis C virus and studies of antivirals

    Pihl, A. F., Offersgaard, A. F., Mathiesen, C. K., Prentø, Jannick, Fahnøe, Ulrik, Krarup, H., Bukh, Jens & Gottwein, Judith Margarete, 2018, In: Scientific Reports. 8, 1, 13 p., 17505.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Hypervariable Region 1 in Envelope Protein 2 of Hepatitis C Virus: A Linchpin in Neutralizing Antibody Evasion and Viral Entry

    Prentø, Jannick & Bukh, Jens, 2018, In: Frontiers in Immunology. 9, 11 p., 2146.

    Research output: Contribution to journalReviewResearchpeer-review

  62. Published

    Outcome and adverse events in patients with chronic hepatitis C treated with direct-acting antivirals: A clinical randomized study

    Sølund, C., Andersen, Ellen Sloth, Mössner, B., Laursen, A. L., Røge, B. T., Kjær, M. S., Gerstoft, Jan, Christensen, P. B., Pedersen, M. S., Schønning, Kristian, Fahnøe, Ulrik, Bukh, Jens & Weis, Nina, 2018, In: European Journal of Gastroenterology and Hepatology. 30, 10, p. 1177-1186 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies

    Humes, D., Ramirez Almeida, Santseharay, Jensen, T. B., Li, Y. P., Gottwein, Judith Margarete & Bukh, Jens, 2018, In: Virology. 522, p. 177-192 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Ribavirin-induced mutagenesis across the complete open reading frame of hepatitis C virus genotypes 1a and 3a

    Mejer, N., Fahnøe, Ulrik, Galli, Andrea, Ramirez Almeida, Santseharay, Benfield, Thomas & Bukh, Jens, 2018, In: Journal of General Virology. 99, 8, p. 1066-1077 12 p., 001095.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. 2017
  66. Published

    Broadening CD4(+) and CD8(+) T Cell Responses against Hepatitis C Virus by Vaccination with NS3 Overlapping Peptide Panels in Cross-Priming Liposomes

    Filskov, J., Mikkelsen, M., Hansen, Paul Robert, Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Andersen, P., Bukh, Jens & Agger, E., Jul 2017, In: Journal of Virology. 91, 14, 18 p., e00130-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A

    Velazquez-Moctezuma, R., Law, M., Bukh, Jens & Prentø, Jannick, Feb 2017, In: PLOS Pathogens. 13, 2, 29 p., 1006214.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Efficient hepatitis c virus genotype 1b core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors

    Pham, Long, Ramirez Almeida, Santseharay, Carlsen, T. H. R., Li, Y., Gottwein, Judith Margarete & Bukh, Jens, 2017, In: Antimicrobial Agents and Chemotherapy. 61, 6, 19 p., e00037-17.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Mouse models of acute and chronic hepacivirus infection

    Billerbeck, E., Wolfisberg, Raphael, Fahnøe, Ulrik, Xiao, J. W., Quirk, C., Luna, J. M., Cullen, J. M., Hartlage, A. S., Chiriboga, L., Ghoshal, K., Lipkin, W. I., Bukh, Jens, Scheel, Troels Kasper Høyer, Kapoor, A. & Rice, C. M., 2017, In: Science. 357, 6347, p. 204-208 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Proposed revision to the taxonomy of the genus Pestivirus, family Flaviviridae

    Smith, D. B., Meyers, G., Bukh, Jens, Gould, E. A., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T., Simmonds, P. & Becher, P., 2017, In: Journal of General Virology. 98, 8, p. 2106-2112 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. 2016
  72. Published

    HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice

    Prentø, Jannick, Verhoye, L., Moctezuma, R. V., Buysschaert, C., Farhoudi, A., Wang, R., Alter, H., Meuleman, P. & Bukh, Jens, Dec 2016, In: Gut. 65, 12, p. 1988-1997 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Hypervariable Region 1 Shielding of Hepatitis C Virus Is a Main Contributor to Genotypic Differences in Neutralization Sensitivity

    Prentø, Jannick, Velazquez-Moctezuma, R., Foung, S. K. H., Law, M. & Bukh, Jens, Dec 2016, In: Hepatology. 64, 6, p. 1881-1892 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Proposed update to the taxonomy of the genera Hepacivirus and Pegivirus within the Flaviviridae family

    Smith, D. B., Becher, P., Bukh, Jens, Gould, E. A., Meyers, G., Monath, T., Muerhoff, A. S., Pletnev, A., Rico-Hesse, R., Stapleton, J. T. & Simmonds, P., Nov 2016, In: Journal of General Virology. 97, p. 2894-2907 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  75. Published

    Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir

    Ramirez Almeida, Santseharay, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Nov 2016, In: Gastroenterology. 151, 5, p. 973-985.e2

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Neutralizing antibodies in patients with chronic hepatitis C and correlation to liver cirrhosis and estimated duration of infection

    Pedersen, J., Lundbo, L. F., Krarup, H., Bukh, Jens & Weis, Nina, Oct 2016, In: Journal of Medical Virology. 88, 10, p. 1791-1803 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    The history of hepatitis C virus (HCV): Basic research reveals unique features in phylogeny, evolution and the viral life cycle with new perspectives for epidemic control

    Bukh, Jens, Oct 2016, In: Journal of Hepatology. 65, 1 Suppl., p. S2-S21

    Research output: Contribution to journalReviewResearchpeer-review

  78. Published

    Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against specific antagomir

    Li, Y., Pham, Long, Uzcategui, N. & Bukh, Jens, Jun 2016, In: Journal of General Virology. 97, p. 1381-1394

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. 2015
  80. Published

    Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance

    Jensen, S. B., Serre, S. B. N., Humes, D. G., Ramirez Almeida, Santseharay, Li, Y., Bukh, Jens & Gottwein, Judith Margarete, Dec 2015, In: Antimicrobial Agents and Chemotherapy. 59, 12, p. 7426-7436 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

    Bukh, Jens, Engle, R. E., Faulk, K., Wang, R. Y., Farci, P., Alter, H. J. & Purcell, R. H., Sep 2015, In: Journal of Virology. 89, 17, p. 9128-9132 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published

    Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant

    Mathiesen, C. K., Prentø, Jannick, Meredith, L. W., Jensen, T. B., Krarup, H., McKeating, J. A., Gottwein, Judith Margarete & Bukh, Jens, Aug 2015, In: Journal of Virology. 89, 15, p. 7758-7775 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  83. Published

    Cell culture system of a hepatitis C genotype 3a and 2a chimera: Patent #: 8,945,584

    Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 3 Feb 2015, IPC No. A61K 39/29 (20060101); C12N 15/06 (20060101); C12Q 1/02 (20060101); C07H 21/00 (20060101); C12N 7/02 (20060101); A61K 39/12 (20060101), Patent No. WO2008/125117, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050083

    Research output: Patent

  84. Published

    Infectious hepatitis C viruses of genotype 3A and 4A and uses thereof: Patent #: 8,946,398

    Gottwein, Judith Margarete, Scheel, T. K. H., Purcell, R. E. & Bukh, Jens, 3 Feb 2015, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2011/038737, 26 Jul 2012, Priority date 16 Sep 2010, Priority No. PCT/DK2010/050236

    Research output: Patent

  85. Published

    Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77

    Li, Y., Ramirez Almeida, Santseharay, Mikkelsen, L. & Bukh, Jens, Jan 2015, In: Journal of Virology. 89, 1, p. 811-23 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. 2014
  87. Published

    Breadth of neutralization and synergy of clinically relevant human monoclonal antibodies against HCV genotypes 1a, 1b, 2a, 2b, 2c, and 3a

    Carlsen, T. H. R., Pedersen, J., Prentø, Jannick, Giang, E., Keck, Z., Mikkelsen, L. S., Law, M., Foung, S. K. H. & Bukh, Jens, Nov 2014, In: Hepatology. 60, 5, p. 1551-62 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  88. Published

    Transfusion-associated hepatitis before the screening of blood for hepatitis risk factors

    Engle, R. E., Bukh, Jens, Alter, H. J., Emerson, S. U., Trenbeath, J. L., Nguyen, H. T., Brockington, A., Mitra, T. & Purcell, R. H., Nov 2014, In: Transfusion. 54, 11, p. 2833-41 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Infectious genotype 1a, 1b, 2a, 2b, 3a, 5a, 6a and 7a hepatitis C virus lacking the hypervariable region 1 (HVR1): Patent #: 8,846,891

    Prentø, Jannick, Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens & Jensen, T. B., 30 Sep 2014, IPC No. C07H 21/04 (20060101); C07H 21/02 (20060101), Patent No. WO2010/022727, 4 Mar 2010, Priority date 7 Aug 2009, Priority No. PCT/DK2009/050197

    Research output: Patent

  90. Published

    Genetic variation in toll-like receptors and retinoic acid-inducible gene I and outcome of hepatitis C virus infection: a candidate gene association study

    Clausen, L. N., Ladelund, S., Weis, Nina, Bukh, Jens & Benfield, Thomas, Aug 2014, In: Journal of Viral Hepatitis. 21, 8, p. 578-84 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    Hepatitis C virus expressing reporter tagged NS5A protein: Patent #: 8,772,022

    Gottwein, Judith Margarete, Scheel, T. K. H., Bukh, Jens, Prentø, Jannick & Jensen, T. B., 8 Jul 2014, IPC No. C12N 15/00 (20060101); C12N 5/00 (20060101); C12N 7/00 (20060101); C12N 15/64 (20060101); A61K 39/29 (20060101); C12N 7/01 (20060101), Patent No. WO2010/037403, 8 Apr 2010, Priority date 5 Oct 2009, Priority No. PCT/DK2009/050263

    Research output: Patent

  92. Published

    Comparative analysis of the molecular mechanisms of recombination in hepatitis C virus

    Galli, A. & Bukh, Jens, Jun 2014, In: Trends in Microbiology. 22, 6, p. 354-64 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6

    Mathiesen, C. K., Jensen, T. B., Prentø, Jannick, Krarup, H., Nicosia, A., Law, M., Bukh, Jens & Gottwein, Judith Margarete, Jun 2014, In: Virology. 458-459, p. 190-208 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents

    Xiao, F., Fofana, I., Heydmann, L., Barth, H., Soulier, E., Habersetzer, F., Doffoël, M., Bukh, Jens, Patel, A. H., Zeisel, M. B. & Baumert, T. F., May 2014, In: P L o S Pathogens. 10, 5, p. 1-15 16 p., e1004128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  95. Published

    Efficient cell culture system for hepatitis C virus genotype 2B: Patent #: 8,663,653

    Gottwein, Judith Margarete, Knudsen, M. L., Scheel, T. K. H. & Bukh, Jens, 31 Mar 2014, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12N 1/20 (20060101); C12N 5/071 (20100101); C12N 15/00 (20060101); C12Q 1/70 (20060101), Patent No. WO2010/017818, 18 Feb 2010, Priority date 24 Jul 2009, Priority No. PCT/DK2009/050189

    Research output: Patent

  96. Published

    Differential sensitivity of 5'UTR-NS5A recombinants of hepatitis C virus genotypes 1-6 to protease and NS5A inhibitors

    Li, Y., Ramirez, S., Humes, D., Jensen, S. B., Gottwein, Judith Margarete & Bukh, Jens, Mar 2014, In: Gastroenterology. 146, 3, p. 812-821.e4 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Highly efficient infectious cell culture of three hepatitis C virus genotype 2b strains and sensitivity to lead protease, nonstructural protein 5A, and polymerase inhibitors

    Ramirez, S., Li, Y., Jensen, S. B., Pedersen, J., Gottwein, Judith Margarete & Bukh, Jens, Feb 2014, In: Hepatology. 59, 2, p. 395-407 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    Hypervariable region 1 deletion and required adaptive envelope mutations confer decreased dependency on scavenger receptor class B type I and low-density lipoprotein receptor for hepatitis C virus

    Prentø, Jannick, Serre, S. B. N., Ramirez, S., Nicosia, A. & Bukh, Jens, Feb 2014, In: Journal of Virology. 88, 3, p. 1725-39 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource

    Smith, D. B., Bukh, Jens, Kuiken, C., Muerhoff, A. S., Rice, C. M., Stapleton, J. T. & Simmonds, P., Jan 2014, In: Hepatology. 59, 1, p. 318-27 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  100. Published

    Nationwide experience of treatment with protease inhibitors in chronic hepatitis C patients in denmark: identification of viral resistance mutations

    Sølund, C., Krarup, H., Ramirez Almeida, Santseharay, Thielsen, P., Røge, B. T., Lunding, S., Barfod, Toke Seierøe, Madsen, Lone Galmstrup, Tarp, B., Christensen, P. B., Gerstoft, Jan, Laursen, A. L., Bukh, Jens, Weis, Nina & DANHEP Group, D. G., 2014, In: PLOS ONE. 9, 12, p. 1-20 20 p., e113034.

    Research output: Contribution to journalJournal articleResearchpeer-review

  101. 2013
  102. Published

    Efficient cell culture system for hepatitis C virus genotype 5A: Patent #: 8,618,275

    Jensen, T. B., Gottwein, Judith Margarete, Scheel, T. K. H., Eugen-Olsen, J. & Bukh, Jens, 31 Dec 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2008/141651, 27 Nov 2008, Priority date 19 May 2008, Priority No. PCT/DK2008/050113

    Research output: Patent

  103. Published

    Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor

    Gottwein, Judith Margarete, Jensen, S. B., Serre, S. B. N., Ghanem, L., Scheel, Troels Kasper Høyer, Jensen, T. B., Krarup, H., Uzcategui, N., Mikkelsen, L. S. & Bukh, Jens, Dec 2013, In: Antimicrobial Agents and Chemotherapy. 57, 12, p. 6034-49 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  104. Published

    Identification of alpha interferon-induced envelope mutations of hepatitis C virus in vitro associated with increased viral fitness and interferon resistance

    Serre, S. B. N., Krarup, H. B., Bukh, Jens & Gottwein, Judith Margarete, Dec 2013, In: Journal of Virology. 87, 23, p. 12776-93 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  105. Published

    Persistent human hepatitis B virus infection in cynomolgus monkeys: a novel animal model in the search for a cure?

    Bukh, Jens, Lanford, R. E. & Purcell, R. H., Nov 2013, In: Hepatology. 58, 5, p. 1533-6 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  106. Published

    Efficient cell culture system for hepatitis C virus genotype 6A: Patent #: 8,569,472

    Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 29 Oct 2013, IPC No. C07H 21/00 (20060101); C12N 7/00 (20060101); A61K 39/295 (20060101); A61K 39/12 (20060101); A61K 39/29 (20060101), Patent No. WO2009/080052, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050332

    Research output: Patent

  107. Published

    Efficient cell culture system for hepatitis C virus genotype 1a and 1b: Patent #: 8,563,706

    Scheel, T. K. H., Gottwein, Judith Margarete, Prentø, Jannick, Jensen, T. B. & Bukh, Jens, 22 Oct 2013, IPC No. C07H 21/00 (20060101); A61K 39/29 (20060101); A61K 39/12 (20060101); A61K 39/295 (20060101); C12N 7/00 (20060101), Patent No. WO2009/080053, 2 Jul 2009, Priority date 19 Dec 2008, Priority No. PCT/DK2008/050333

    Research output: Patent

  108. Published

    Analysis of hepatitis C virus core/NS5A protein co-localization using novel cell culture systems expressing core-NS2 and NS5A of genotypes 1-7

    Galli, A., Scheel, Troels Kasper Høyer, Prentø, Jannick, Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Oct 2013, In: The Journal of general virology. 94, Pt 10, p. 2221-35 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  109. Published

    Viral hepatitis: Cell-culture-derived HCV--a promising vaccine antigen

    Gottwein, Judith Margarete & Bukh, Jens, Sep 2013, In: Nature Reviews. Gastroenterology & Hepatology. 10, 9, p. 508-9 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  110. Published

    Efficient cell culture system for hepatitis C virus genotype 7a: Patent #: 8,506,969

    Gottwein, Judith Margarete, Scheel, T. K. H., Jensen, T. B. & Bukh, Jens, 13 Aug 2013, IPC No. A61K 39/12 (20060101); A61K 39/29 (20060101); C12Q 1/70 (20060101); C12N 15/00 (20060101); C12N 5/071 (20100101); C12N 1/20 (20060101), Patent No. WO2010/017819, 18 Feb 2010, Priority date 31 Jul 2009, Priority No. PCT/DK2009/050193

    Research output: Patent

  111. Published

    Adaptive mutations allow establishment of JFH1-based cell culture systems for hepatitis C virus genotype 4A: Patent #: 8,454,974

    Scheel, T. K. H., Gottwein, Judith Margarete, Eugen-Olsen, J. & Bukh, Jens, 4 Jun 2013, IPC No. A61K 39/29 (20060101); C07H 21/00 (20060101); C12N 15/06 (20060101); C12N 7/02 (20060101); C12Q 1/02 (20060101), Patent No. WO2008/125119, 23 Oct 2008, Priority date 11 Apr 2008, Priority No. PCT/DK2008/050085

    Research output: Patent

  112. Published

    Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses

    Gottwein, Judith Margarete, Jensen, S. B., Li, Y., Ghanem, L., Scheel, Troels Kasper Høyer, Serre, S. B. N., Mikkelsen, L. & Bukh, Jens, Mar 2013, In: Antimicrobial Agents and Chemotherapy. 57, 3, p. 1291-303 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  113. Published

    Productive homologous and non-homologous recombination of hepatitis C virus in cell culture

    Scheel, Troels Kasper Høyer, Galli, A., Li, Y., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, Mar 2013, In: P L o S Pathogens. 9, 3, p. 1-12 13 p., e1003228.

    Research output: Contribution to journalJournal articleResearchpeer-review

  114. Published

    A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans

    Law, J. L. M., Chen, C., Wong, J., Hockman, D., Santer, D. M., Frey, S. E., Belshe, R. B., Wakita, T., Bukh, Jens, Jones, C. T., Rice, C. M., Abrignani, S., Tyrrell, D. L. & Houghton, M., 2013, In: PloS one. 8, 3, p. 1-7 8 p., e59776.

    Research output: Contribution to journalJournal articleResearchpeer-review

  115. Published

    Characterization of hepatitis C virus recombinants with chimeric E1/E2 envelope proteins and identification of single amino acids in the E2 stem region important for entry

    Carlsen, T. H. R., Scheel, Troels Kasper Høyer, Ramirez Almeida, Santseharay, Foung, S. K. H. & Bukh, Jens, 2013, In: Journal of Virology. 87, 3, p. 1385-99 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  116. Published

    Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein

    Keck, Z., Wang, W., Wang, Y., Lau, P., Carlsen, T. H. R., Prentø, Jannick, Xia, J., Patel, A. H., Bukh, Jens & Foung, S. K. H., 2013, In: Journal of Virology. 87, 1, p. 37-51 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  117. Published

    Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies

    Pedersen, J. L., Carlsen, T. H. R., Prentø, Jannick, Ramirez, S., Jensen, T. B., Forns, X., Alter, H., Foung, S. K. H., Law, M., Gottwein, Judith Margarete, Weis, Nina & Bukh, Jens, 2013, In: Hepatology. 58, 5, p. 1587-1597 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  118. Published

    Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses

    Pedersen, J., Jensen, T. B., Carlsen, T. H. R., Schønning, Kristian, Christensen, P. B., Laursen, A. L., Krarup, H., Bukh, Jens & Weis, Nina, 2013, In: P L o S One. 8, 5, 16 p., e62674.

    Research output: Contribution to journalJournal articleResearchpeer-review

  119. 2012
  120. Published

    Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system

    Li, Y., Ramirez, S., Jensen, S. B., Purcell, R. H., Gottwein, Judith Margarete & Bukh, Jens, 27 Nov 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 48, p. 19757-62 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  121. Published

    Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells

    Saeed, M., Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Marukian, S., Dustin, L. B., Bukh, Jens & Rice, C. M., Oct 2012, In: Antimicrobial Agents and Chemotherapy. 56, 10, p. 5365-73 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  122. Published

    Negative HCV-RNA 2 weeks after initiation of treatment predicts sustained virological response to pegylated interferon alfa-2a and ribavirin in patients with chronic hepatitis C

    Christensen, P. B., Krarup, H. B., Laursen, A. L., Madsen, P. H., Pedersen, C., Schlichting, P., Orholm, M., Larsen, H. R., Bukh, Jens & Krogsgaard, K., Sep 2012, In: Scandinavian Journal of Gastroenterology. 47, 8-9, p. 1115-1119

    Research output: Contribution to journalJournal articleResearchpeer-review

  123. Published

    Animal models for the study of hepatitis C virus infection and related liver disease

    Bukh, Jens, May 2012, In: Gastroenterology. 142, 6, p. 1279-1287.e3 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  124. Published

    Human broadly neutralizing antibodies to the envelope glycoprotein complex of hepatitis C virus

    Giang, E., Dorner, M., Prentø, Jannick, Dreux, M., Evans, M. J., Bukh, Jens, Rice, C. M., Ploss, A., Burton, D. R. & Law, M., 17 Apr 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 16, p. 6205-10 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  125. Published

    Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature

    Sabo, M. C., Luca, V. C., Ray, S. C., Bukh, Jens, Fremont, D. H. & Diamond, M. S., 20 Jan 2012, In: Virology. 422, 2, p. 174-84 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  126. Published

    Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems

    Scheel, Troels Kasper Høyer, Prentø, Jannick, Carlsen, T. H. R., Mikkelsen, L. S., Gottwein, Judith Margarete & Bukh, Jens, 2012, In: P L o S Pathogens. 8, 5, p. 1-16 17 p., e1002696.

    Research output: Contribution to journalJournal articleResearchpeer-review

  127. Published

    Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate

    Keck, Z., Xia, J., Wang, Y., Wang, W., Krey, T., Prentø, Jannick, Carlsen, T., Li, A. Y., Patel, A. H., Lemon, S. M., Bukh, Jens, Rey, F. A. & Foung, S. K. H., 2012, In: P L o S Pathogens. 8, 4, 21 p., e1002653.

    Research output: Contribution to journalJournal articleResearchpeer-review

  128. Published

    Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains

    Li, Y., Ramirez, S., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Mikkelsen, L., Purcell, R. H. & Bukh, Jens, 2012, In: Proceedings of the National Academy of Sciences USA (PNAS). 109, 18, p. E1101-E1110 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  129. 2011
  130. Published

    Correlates of spontaneous clearance of hepatitis C virus in a Danish human immunodeficiency virus type 1 cohort

    Clausen, L. N., Weis, Nina, Schønning, Kristian, Fenger, M., Krarup, H., Bukh, Jens & Benfield, Thomas, Oct 2011, In: Scandinavian Journal of Infectious Diseases. 43, 10, p. 798-803 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  131. Published

    FLAVIVIRDAE

    Bukh, Jens, Oct 2011, Virus Taxonomy: 9. report of the International Committee on Taxonomy of Viruses. Mq King, A., Lefkowitz, E., Adams, M. J. & Carstens, E. B. (eds.). 1 ed. Elsevier, p. 1003-1020 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  132. Published

    Efficient Culture Adaptation of Hepatitis C Virus Recombinants with Genotype-Specific Core-NS2 by Using Previously Identified Mutations

    Scheel, Troels Kasper Høyer, Gottwein, J. M., Carlsen, T. H. R., Li, Y., Jensen, T. B., Spengler, U., Weis, Nina & Bukh, Jens, Mar 2011, In: Journal of Virology. 85, 6, p. 2891-2906 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  133. Published

    Enhanced and sustained CD8+ T cell responses with an adenoviral vector-based hepatitis C virus vaccine encoding NS3 linked to the MHC class II chaperone protein invariant chain

    Mikkelsen, M., Holst, Peter Johannes, Bukh, Jens, Thomsen, Allan Randrup & Christensen, Jan Pravsgaard, 15 Feb 2011, In: Journal of Immunology. 186, 4, p. 2355-64 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  134. Published

    Effectiveness of treatment with pegylated interferon and ribavirin in an unselected population of patients with chronic hepatitis C: a Danish nationwide cohort study

    Hansen, N., Obel, Niels, Christensen, P., Kjær, M. S., Laursen, A. L., Krarup, H. B., Møller, A., Schliehting, P., Bukh, Jens, Weis, Nina, Danish Database for Hepatitis B and C (DANHEP)- group, D. D. F. H. B. A. C. (. G. & Nørregaard, Peter, 1 Jan 2011, In: B M C Infectious Diseases. 11, p. 177 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  135. Published

    Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A

    Gottwein, J. M., Jensen, T. B., Mathiesen, C. K., Meuleman, P., Serre, S. B. N., Lademann, J. B., Ghanem, L., Scheel, Troels Kasper Høyer, Leroux-Roels, G. & Bukh, Jens, 2011, In: Journal of Virology. 85, 17, p. 8913-28 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  136. Published

    Differential efficacy of protease inhibitors against HCV genotypes 2a, 3a, 5a, and 6a NS3/4A protease recombinant viruses

    Gottwein, J. M., Scheel, Troels Kasper Høyer, Jensen, T. B., Ghanem, L. & Bukh, Jens, 2011, In: Gastroenterology Today. 141, 3, p. 1067-1079 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  137. Published

    Hepatitis C homolog in dogs with respiratory illness

    Bukh, Jens, 2011, In: PNAS Early Edition. 108, 31, p. 12563-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  138. Published
  139. Published

    Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

    Prentø, Jannick, Jensen, T. B., Meuleman, P., Serre, S., Scheel, Troels Kasper Høyer, Leroux-Roels, G., Gottwein, J. & Bukh, Jens, 2011, In: Journal of Virology. 85, 5, p. 2224-34 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  140. Published

    In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

    Meuleman, P., Bukh, Jens, Verhoye, L., Farhoudi, A., Vanwolleghem, T., Wang, R. Y., Desombere, I., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2011, In: Hepatology. 53, 3, p. 755-62

    Research output: Contribution to journalJournal articleResearchpeer-review

  141. Published

    Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

    Clausen, L. N., Weis, Nina, Astvad, K., Schønning, Kristian, Fenger, M., Krarup, Helene, Bukh, Jens & Benfield, Thomas, 2011, In: Journal of Viral Hepatitis. 18, 4, p. e66-e74 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  142. Published

    MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR

    Li, Y., Gottwein, J., Scheel, Troels Kasper Høyer, Jensen, T. B. & Bukh, Jens, 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 12, p. 4991-4996

    Research output: Contribution to journalJournal articleResearchpeer-review

  143. Published

    Neutralizing antibodies to hepatitis C virus in perinatally infected children followed up prospectively

    Meunier, J., Bukh, Jens, Diaz, G., Tovo, P., Casadei, A. M., Quinti, I., Iorio, R., Emerson, S., Purcell, R. H. & Farci, P., 2011, In: Journal of Infectious Diseases. 204, 11, p. 1741-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  144. Published

    Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step

    Sabo, M. C., Luca, V. C., Prentø, Jannick, Hopcraft, S. E., Blight, K. J., Yi, M., Lemon, S. M., Ball, J. K., Bukh, Jens, Evans, M. J., Fremont, D. H. & Diamond, M. S., 2011, In: Journal of Virology. 85, 14, p. 7005-19 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  145. Published

    Non-genotype-specific role of the hepatitis C virus 5' untranslated region in virus production and in inhibition by interferon

    Li, Y., Ramirez, S., Gottwein, J. M. & Bukh, Jens, 2011, In: Virology: Research and Treatment. 421, 2, p. 222-34 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  146. Published

    Recombinant HCV variants with NS5A from genotypes 1-7 have different sensitivities to an NS5A inhibitor but not interferon-a

    Scheel, Troels Kasper Høyer, Gottwein, J. M., Mikkelsen, L. S., Jensen, T. B. & Bukh, Jens, 2011, In: Gastroenterology Today. 140, 3, p. 1032-42 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  147. Published

    The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae

    Stapleton, J. T., Foung, S., Muerhoff, A. S., Bukh, Jens & Simmonds, P., 2011, In: Journal of General Virology. 92, Pt 2, p. 233-46 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  148. Published

    Transmission of clonal hepatitis C virus genomes reveals the dominant but transitory role of CD8¿ T cells in early viral evolution

    Callendret, B., Bukh, Jens, Eccleston, H. B., Heksch, R., Hasselschwert, D. L., Purcell, R. H., Hughes, A. L. & Walker, C. M., 2011, In: Journal of Virology. 85, 22, p. 11833-45 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  149. Published

    Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus

    Meunier, J., Gottwein, J. M., Houghton, M., Russell, R. S., Emerson, S. U., Bukh, Jens & Purcell, R. H., 2011, In: Journal of Infectious Diseases. 204, 8, p. 1186-90 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  150. 2010
  151. Published

    Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

    Bukh, Jens, Meuleman, P., Tellier, R., Engle, R. E., Feinstone, S. M., Eder, G., Satterfield, W. C., Govindarajan, S., Krawczynski, K., Miller, R. H., Leroux-Roels, G. & Purcell, R. H., 1 May 2010, In: Journal of Infectious Diseases. 201, 9, p. 1381-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  152. Published

    Molecular and epidemiological profiles of hepatitis C virus genotype 4 in Denmark

    Eriksen, M. B., Jørgensen, L. B., Krarup, H., Laursen, A. L., Christensen, P. B., Møller, A., Schlichting, P., Kuiken, C., Bukh, Jens, Weis, N. & DANHEP Group, D. G., 2010, In: Journal of Medical Virology. 82, 11, p. 1869-1877 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  153. Published

    Molecular evolution of GB virus B hepatitis virus during acute resolving and persistent infections in experimentally infected tamarins

    Takikawa, S., Engle, R. E., Faulk, K. N., Emerson, S. U., Purcell, R. H. & Bukh, Jens, 2010, In: Journal of General Virology. 91, Pt 3, p. 727-33 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  154. Published

    Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

    Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Callendret, B., Li, Y., Eccleston, H. B., Engle, R. E., Govindarajan, S., Satterfield, W., Purcell, R. H., Walker, C. M. & Bukh, Jens, 2010, In: Journal of Virology. 84, 10, p. 5277-93 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  155. 2009
  156. Published

    DELETION OF HYPERVARIABLE REGION 1 (HVR1) OF E2 FROM HCV GENOTYPES 1-6 HAS DIFFERENTIAL EFFECT ON INFECTIVITY IN VITRO AND CAUSES INCREASED SUSCEPTIBILITY TO NEUTRALIZATION

    Prentø, Jannick, Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Serre, S. & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S34-S34

    Research output: Contribution to journalJournal articleResearchpeer-review

  157. Published

    Development and characterization of hepatitis C virus genotype 1-7 cell culture systems: role of CD81 and scavenger receptor class B type I and effect of antiviral drugs

    Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Jensen, T. B., Lademann, J. B., Prentø, Jannick, Knudsen, M. L., Hoegh, A. M. & Bukh, Jens, 2009, In: Hepatology. 49, 2, p. 364-77 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  158. Published

    MONOCISTRONIC HEPATITIS C REPORTER VIRUS RECOMBINANTS OF ALL MAJOR GENOTYPES EXPRESSING ENHANCED GREEN FLUORESCENT PROTEIN TAGGED NS5A PROTEIN

    Gottwein, Judith Margarete, Lademann, J. B., Scheel, Troels Kasper Høyer, Jensen, T. B., Prentø, Jannick & Bukh, Jens, 2009, In: Journal of Hepatology. 50, p. S33-S33

    Research output: Contribution to journalJournal articleResearchpeer-review

  159. Published

    Mutational analysis of the hepatitis C virus E1 glycoprotein in retroviral pseudoparticles and cell-culture-derived H77/JFH1 chimeric infectious virus particles

    Russell, R. S., Kawaguchi, K., Meunier, J., Takikawa, S., Faulk, K., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 2009, In: Journal of Viral Hepatitis. 16, 9, p. 621-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  160. Published

    Predictors of antiviral treatment initiation in hepatitis C virus-infected patients: a Danish cohort study

    Hansen, N., Obel, Niels, Christensen, P. B., Krarup, Helene, Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A., Schlichting, P., Kromann-Andersen, H., Bukh, Jens, Weis, Nina, Hansen, N., Obel, Niels, Christensen, P. B., Krarup, H., Laursen, A. L., Clausen, M. R., Lunding, S., Møller, A., Schlichting, P., Kromann-Andersen, H., Bukh, J. & Weis, Nina, 2009, In: Journal of Viral Hepatitis. 16, 9, p. 659-65 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  161. 2008
  162. Published

    Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus

    Russell, R. S., Meunier, J., Takikawa, S., Faulk, K., Engle, R. E., Bukh, Jens, Purcell, R. H. & Emerson, S. U., 18 Mar 2008, In: PNAS Early Edition. 105, 11, p. 4370-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  163. Published

    Cutting the gordian knot-development and biological relevance of hepatitis C virus cell culture systems.

    Gottwein, Judith Margarete & Bukh, Jens, 2008, In: Advances in Virus Research. 71, p. 51-133 82 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  164. Published

    Development of JFH1-based cell culture systems for hepatitis C virus genotype 4a and evidence for cross-genotype neutralization

    Scheel, Troels Kasper Høyer, Gottwein, Judith Margarete, Jensen, T. B., Prentø, Jannick, Høegh, A. M., Alter, H. J., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Proceedings of the National Academy of Science of the United States of America. 105, 3, p. 997-1002 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  165. Published

    Development of a TaqMan assay for the six major genotypes of hepatitis C virus: Comparison with commercial assays

    Engle, R. E., Russell, R. S., Purcell, R. H. & Bukh, Jens, 2008, In: Journal of Medical Virology. 80, 1, p. 72-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  166. Published

    Hepatitis C: the virus and studies of its lifecycle in cell culture systems

    Bukh, Jens, Gottwein, J. M., Scheel, T. K. & Forns, X., 2008, 100 Key Questions on Hepatitis C. Forns, X. (ed.). 1 ed. Barcelona, Spain: Permanyer Publications, Vol. 1. p. 1-15 14 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  167. Published

    Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection

    Jensen, T. B., Gottwein, Judith Margarete, Scheel, Troels Kasper Høyer, Høgh, A. M., Eugen-Olsen, J. & Bukh, Jens, 2008, In: Journal of Infectious Diseases. 198, 12, p. 1756-1765 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  168. Published

    Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived

    Bukh, Jens, Engle, R. E., Govindarajan, S. & Purcell, R. H., 2008, In: Journal of Medical Virology. 80, 1, p. 87-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  169. Published

    Intragenotypic JFH1 based recombinant hepatitis C virus produces high levels of infectious particles but causes increased cell death.

    Mateu, G., Donis, R. O., Wakita, T., Bukh, Jens & Grakoui, A., 2008, In: Virology. 376, 2, p. 397-407 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  170. Published

    Isolation and characterization of broadly neutralizing human monoclonal antibodies to the e1 glycoprotein of hepatitis C virus

    Meunier, J., Russell, R. S., Goossens, V., Priem, S., Walther, H., Depla, E., Union, A., Faulk, K. N., Bukh, Jens, Emerson, S. U. & Purcell, R. E., 2008, In: Journal of Virology. 82, 2, p. 966-73 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  171. Published

    Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain.

    Vanwolleghem, T., Bukh, Jens, Meuleman, P., Desombere, I., Meunier, J., Alter, H., Purcell, R. H. & Leroux-Roels, G., 2008, In: Hepatology. 47, 6, p. 1846-1855 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  172. Published

    Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain.

    Bukh, Jens, Thimme, R., Meunier, J., Faulk, K., Spangenberg, H. C., Chang, K., Satterfield, W., Chisari, F. V. & Purcell, R. H., 2008, In: Journal of Virology. 82, 16, p. 8183-95 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  173. 2007
  174. Published

    Current status of a hepatitis C vaccine: encouraging results but significant challenges ahead

    Mikkelsen, M. & Bukh, Jens, 2007, In: Current Infectious Disease Reports. 9, 2, p. 94-101 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  175. Published

    Hepatitis C virus host cell interactions uncovered

    Gottwein, J. & Bukh, Jens, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 33, p. 13215-6

    Research output: Contribution to journalJournal articleResearchpeer-review

  176. Published

    In vivo study of the HC-TN strain of hepatitis C virus recovered from a patient with fulminant hepatitis: RNA transcripts of a molecular clone (pHC-TN) are infectious in chimpanzees but not in Huh7.5 cells

    Sakai, A., Takikawa, S., Thimme, R., Meunier, J. C., Spangenberg, H. C., Govindarajan, S., Farci, P., Emerson, S. U., Chisari, F. V., Purcell, R. H. & Bukh, Jens, 2007, In: Journal of Virology. 81, 13, p. 7208-7219 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  177. Published

    Monitoring of hepatitis C virus quasispecies in chronic infection by matrix-assisted laser desorption ionization-time of flight mass spectrometry mutation detection

    Yea, C., Bukh, Jens, Ayers, M., Roberts, E., Krajden, M. & Tellier, R., 2007, In: Journal of Clinical Microbiology. 45, 3, p. 1053-1057 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  178. Published

    Robust hepatitis C genotype 3a cell culture releasing adapted intergenotypic 3a/2a (S52/JFH1) viruses

    Gottwein, J. M., Scheel, Troels Kasper Høyer, Hoegh, A. M., Lademann, J. B., Eugen-Olsen, J., Lisby, G. & Bukh, Jens, 2007, In: Gastroenterology. 133, 5, p. 1614-26 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  179. 2006
  180. Published

    A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes.

    Kuiken, C., Combet, C., Bukh, Jens, Shin-I, T., Deleage, G., Mizokami, M., Richardson, R., Sablon, E., Yusim, K., Pawlotsky, J., Simmonds, P. & Los Alamos HIV Database Group, L. A. H. D. G., 2006, In: Hepatology. 44, 5, p. 1355-61 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  181. Published

    A milestone for hepatitis C virus research: a virus generated in cell culture is fully viable in vivo.

    Bukh, Jens & Purcell, R. H., 2006, In: Proceedings of the National Academy of Sciences of the United States of America. 103, 10, p. 3500-1 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  182. Published

    Functional analyses of GB virus B p13 protein: Development of a recombinant GB virus B hepatitis virus with a p7 protein

    Takikawa, S., Engle, R. E., Emerson, S. U., Purcell, R. H., St Claire, M. & Bukh, Jens, 2006, In: Proceedings of the National Academy of Science of the United States of America. 103, 9, p. 3345-50 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  183. Published

    Hepatitis C hos hiv-inficerede patienter

    Bukh, Jens & Nielsen, J. O., 2006, In: Ugeskrift for læger. 168, 42, p. 3599-

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 12437